Ikezaki K, Han D H, Kawano T, Kinukawa N, Fukui M
Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Stroke. 1997 Dec;28(12):2513-7. doi: 10.1161/01.str.28.12.2513.
The goal of the present study was to clarify whether South Korean patients with moyamoya disease have clinical features similar to those of Japanese patients.
From 26 South Korean neurosurgical institutes, 296 definite cases were collected and analyzed statistically. These cases were then compared with 731 Japanese definite cases registered to the Research Committee on Moyamoya Disease of the Ministry of Health and Welfare, Japan.
The Korean age distribution patterns showed two peaks that were similar to those seen in Japanese patients. The incidence of adult moyamoya disease in South Korea, however, was 20% higher than that in Japanese patients. The family occurrence rate was 1.8% in Koreans. The incidence of cerebral infarction and bleeding in Koreans was statistically higher, whereas transient ischemic attack and seizure were less than those in Japanese subjects. The incidence of infarction in children and that of hemorrhage in both children and adults were also statistically higher in Koreans. The incidence of hemorrhage was higher in females than in males. Both the age at onset and sex affected the disease type. Although most Japanese patients underwent direct bypass surgery and/or combined indirect bypass procedures, single encephaloduroar-teriosynangiosis was performed on 87.6% of all surgical cases in Koreans. Despite the higher incidence of hemorrhagic type in South Korea, the outcomes of the patients were similar to those of the Japanese patients.
This study suggests that the clinical background of moyamoya disease in South Korea is essentially similar to that in Japan.
本研究旨在阐明韩国烟雾病患者是否具有与日本患者相似的临床特征。
从26家韩国神经外科机构收集了296例确诊病例并进行统计学分析。然后将这些病例与向日本厚生省烟雾病研究委员会登记的731例日本确诊病例进行比较。
韩国患者的年龄分布模式呈现出两个高峰，与日本患者相似。然而，韩国成人烟雾病的发病率比日本患者高20%。韩国人的家族发病率为1.8%。韩国人发生脑梗死和出血的发生率在统计学上更高，而短暂性脑缺血发作和癫痫发作则低于日本受试者。韩国儿童脑梗死的发生率以及儿童和成人出血的发生率在统计学上也更高。女性出血的发生率高于男性。发病年龄和性别均影响疾病类型。尽管大多数日本患者接受了直接搭桥手术和/或联合间接搭桥手术，但韩国87.6%的手术病例采用了单纯脑-硬膜-动脉-血管融合术。尽管韩国出血型的发病率较高，但患者的预后与日本患者相似。
本研究表明，韩国烟雾病的临床背景与日本基本相似。
