Mullen T J, Berger R D, Oman C M, Cohen R J
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA.
J Vestib Res. 1998 Jan-Feb;8(1):95-105.
In a study of 18 human subjects, we applied a new technique, estimation of the transfer function between instantaneous lung volume (ILV) and instantaneous heart rate (HR), to assess autonomic activity during motion sickness. Two control recordings of ILV and electrocardiogram (ECG) were made prior to the development of motion sickness. During the first, subjects were seated motionless, and during the second they were seated rotating sinusoidally about an earth vertical axis. Subjects then wore prism goggles that reverse the left-right visual field and performed manual tasks until they developed moderate motion sickness. Finally, ILV and ECG were recorded while subjects maintained a relatively constant level of sickness by intermittent eye closure during rotation with the goggles. Based on analyses of ILV to HR transfer functions from the three conditions, we were unable to demonstrate a change in autonomic control of heart rate due to rotation alone or due to motion sickness. These findings do not support the notion that moderate motion sickness is manifested as a generalized autonomic response.
在一项针对18名人类受试者的研究中，我们应用了一种新技术，即估算瞬时肺容积（ILV）与瞬时心率（HR）之间的传递函数，以评估晕动病期间的自主神经活动。在晕动病发作之前，进行了两次ILV和心电图（ECG）的对照记录。第一次记录时，受试者静止坐着，第二次记录时，受试者坐在围绕地球垂直轴做正弦旋转的椅子上。然后，受试者戴上能使左右视野颠倒的棱镜护目镜并执行手动任务，直到出现中度晕动病。最后，在受试者戴着护目镜旋转期间通过间歇性闭眼来维持相对稳定的晕动病程度时，记录ILV和ECG。基于对三种情况下ILV至HR传递函数的分析，我们无法证明仅因旋转或因晕动病导致心率的自主控制发生变化。这些发现并不支持中度晕动病表现为全身性自主神经反应这一观点。
