Anand K K, Singh B, Saxena A K, Chandan B K, Gupta V N, Bhardwaj V
Division of Pharmacology, Regional Research Laboratory, Jammu-Tawi, India.
Pharmacol Res. 1997 Oct;36(4):315-21. doi: 10.1006/phrs.1997.0236.
Compound I isolated from fraction TB5 of Terminalia belerica and finally identified as 3,4,5-trihydroxy benzoic acid (gallic acid) was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced physiological and biochemical alterations in the liver. The main parameters studied were hexobarbitone-induced sleep, zoxazolamine induced paralysis, serum levels of transaminases and bilirubin. The hepatic markers assessed were lipid peroxidation, drug metabolising enzymes, glucose-6-phosphatase and triglycerides. Administration of Compound I led to significant reversal of majority of the altered parameters. Our results confirm the presence of hepatoprotective activity in altered parameters. Our results confirm the presence of hepatoprotective activity in Compound I.
从诃子的TB5馏分中分离出的化合物I最终被鉴定为3,4,5-三羟基苯甲酸（没食子酸），对其针对四氯化碳（CCl4）诱导的肝脏生理和生化改变的肝保护活性进行了评估。研究的主要参数为己巴比妥诱导的睡眠、唑沙宗诱导的麻痹、转氨酶和胆红素的血清水平。评估的肝脏标志物为脂质过氧化、药物代谢酶、葡萄糖-6-磷酸酶和甘油三酯。给予化合物I导致大多数改变的参数显著逆转。我们的结果证实了化合物I中存在肝保护活性。
