Mauer M M, Bartness T J
Department of Biology and Psychology, Georgia State University, Atlanta 30303, USA.
Am J Physiol. 1997 Dec;273(6):R2117-23. doi: 10.1152/ajpregu.1997.273.6.R2117.
Long day-housed Siberian hamsters show compensatory mass increases in inguinal (I) white adipose tissue (WAT) after epididymal WAT pad (EWAT) removal (x) but do not increase EWAT mass after IWATx. This study tested whether EWAT is specifically unresponsive to IWATx or whether EWAT lacks responsiveness to body fat deficits in general. We also tested whether the compensatory mass increases that occur after side-specific body fat removal are unilateral or bilateral. Therefore EWAT and/or IWAT was removed unilaterally or bilaterally. The compensatory changes in WAT mass by the intact fat pads were measured 12 wk later. EWAT did not compensate for removal of its contralateral mate. Retroperitoneal WAT and IWAT showed greater compensatory mass increases ipsilateral to the side of fat pad removal when EWAT or IWAT pads were removed unilaterally but not after removal of larger amounts of body fat. These results suggest the following: 1) in general, the greater the lipectomy-induced lipid deficit, the greater is the relative fat pad mass compensation; 2) the restoration of body fat content after lipectomy may involve mechanisms that can detect the side of the lipid deficit and enhance fat deposition on this side; and 3) EWAT does not show compensatory mass increases after lipectomy.
长期笼养的西伯利亚仓鼠在附睾白色脂肪垫（EWAT）切除（x）后，腹股沟（I）白色脂肪组织（WAT）会出现代偿性质量增加，但在IWAT切除后EWAT质量不会增加。本研究测试了EWAT是否对IWAT切除特别无反应，或者EWAT是否总体上对体脂缺乏反应。我们还测试了特定侧体脂去除后发生的代偿性质量增加是单侧的还是双侧的。因此，单侧或双侧切除EWAT和/或IWAT。12周后测量完整脂肪垫对WAT质量的代偿性变化。EWAT不会代偿其对侧脂肪垫的切除。当单侧切除EWAT或IWAT脂肪垫时，腹膜后WAT和IWAT在脂肪垫切除侧的同侧显示出更大的代偿性质量增加，但在切除大量体脂后则没有。这些结果表明：1）一般来说，脂肪切除引起的脂质缺乏越大，相对脂肪垫质量代偿就越大；2）脂肪切除后体脂含量的恢复可能涉及能够检测脂质缺乏侧并增强该侧脂肪沉积的机制；3）EWAT在脂肪切除后不会出现代偿性质量增加。
