• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫活性宿主外周血单个核细胞在细胞培养中的细胞因子产生。

Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hosts.

作者信息

Katial R K, Sachanandani D, Pinney C, Lieberman M M

机构信息

Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC 20307, USA.

出版信息

Clin Diagn Lab Immunol. 1998 Jan;5(1):78-81. doi: 10.1128/CDLI.5.1.78-81.1998.

DOI:10.1128/CDLI.5.1.78-81.1998
PMID:9455885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC121396/
Abstract

The production of interleukin 2 (IL-2) gamma interferon, IL-4, tumor necrosis factor alpha (TNF-alpha), TNF-beta, IL-5, and IL-10 in vitro by peripheral blood mononuclear cells cultured from healthy immunocompetent subjects after mitogen stimulation was determined. The mitogens used were concanavalin A, phytohemagglutinin, pokeweed mitogen, and Staphylococcus aureus Cowen. The results obtained provide a normal range for the production of these cytokines under specified conditions in vitro.

摘要

测定了来自健康免疫活性受试者的外周血单个核细胞在有丝分裂原刺激后体外产生白细胞介素2（IL-2）、γ干扰素、IL-4、肿瘤坏死因子α（TNF-α）、TNF-β、IL-5和IL-10的情况。所使用的有丝分裂原是刀豆球蛋白A、植物血凝素、商陆有丝分裂原和金黄色葡萄球菌考恩株。所获得的结果为这些细胞因子在特定体外条件下的产生提供了一个正常范围。

相似文献

1
Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hosts.免疫活性宿主外周血单个核细胞在细胞培养中的细胞因子产生。
Clin Diagn Lab Immunol. 1998 Jan;5(1):78-81. doi: 10.1128/CDLI.5.1.78-81.1998.
2
Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.丝裂原、细菌和疟原虫刺激的人单核白细胞产生肿瘤坏死因子α和β 。
Infect Immun. 1990 Dec;58(12):3996-4003. doi: 10.1128/iai.58.12.3996-4003.1990.
3
Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells.甲钴胺（维生素B12）对外周血单个核细胞体外细胞因子产生的影响。
J Clin Lab Immunol. 1992;37(4):173-82.
4
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency.短暂性低丙种球蛋白血症和孤立性IgA缺乏症中的细胞因子产生
J Allergy Clin Immunol. 1997 Oct;100(4):556-62. doi: 10.1016/s0091-6749(97)70150-7.
5
Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients.白细胞介素4抑制类风湿性关节炎患者外周血单个核细胞的多克隆免疫球蛋白分泌和细胞因子产生。
J Clin Immunol. 1992 Jan;12(1):36-44. doi: 10.1007/BF00918271.
6
Production of tumor necrosis factor/cachectin by peripheral blood mononuclear cells in patients with systemic lupus erythematosus.
Int Arch Allergy Appl Immunol. 1989;89(4):355-61. doi: 10.1159/000234975.
7
In vitro cytokine synthesis in unstimulated and mitogen-stimulated peripheral blood mononuclear cells from individuals with schizophrenia.精神分裂症患者未刺激和有丝分裂原刺激外周血单个核细胞中的体外细胞因子合成。
J Investig Med. 2019 Oct;67(7):1053-1060. doi: 10.1136/jim-2018-000964. Epub 2019 May 2.
8
Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestion.天然蛋壳膜（NEM）对体外培养外周血单个核细胞细胞因子产生的影响：体外消化后肿瘤坏死因子-α水平的抑制作用增强。
J Med Food. 2012 Apr;15(4):360-8. doi: 10.1089/jmf.2011.0197. Epub 2011 Dec 14.
9
Effect of mycophenolate mofetil (RS-61443) on cytokine production: inhibition of superantigen-induced cytokines.霉酚酸酯（RS-61443）对细胞因子产生的影响：对超抗原诱导的细胞因子的抑制作用。
Immunopharmacology. 1993 Jul-Aug;26(1):11-20. doi: 10.1016/0162-3109(93)90062-u.
10
IL-1 beta, IL-2, IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease.帕金森病患者外周血单个核细胞产生白细胞介素-1β、白细胞介素-2、白细胞介素-6和肿瘤坏死因子-α的情况。
Biomed Pharmacother. 1999 Apr;53(3):141-5. doi: 10.1016/S0753-3322(99)80079-1.

引用本文的文献

1
MH002, a Novel Butyrate-Producing Consortium of Six Commensal Bacterial Strains Has Immune-Modulatory and Mucosal-Healing Properties.MH002，一种由六种共生细菌菌株组成的新型产丁酸盐菌群，具有免疫调节和黏膜修复特性。
Int J Mol Sci. 2025 Jun 26;26(13):6167. doi: 10.3390/ijms26136167.
2
The new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.食蟹猴结核病诊断的新型γ干扰素（IFN-γ）算法
PLoS One. 2024 Dec 16;19(12):e0302349. doi: 10.1371/journal.pone.0302349. eCollection 2024.
3
Beneficial Effects of Phytogenic Feed Additives on Epithelial Barrier Integrity in an In Vitro Co-Culture Model of the Piglet Gut.植物源饲料添加剂对仔猪肠道体外共培养模型上皮屏障完整性的有益影响。
Molecules. 2023 Jan 19;28(3):1026. doi: 10.3390/molecules28031026.
4
T-Cell Immunity in COVID-19-Recovered Individuals and Individuals Vaccinated with the Combined Vector Vaccine Gam-COVID-Vac.COVID-19 康复者和联合载体疫苗 Gam-COVID-Vac 接种者的 T 细胞免疫
Int J Mol Sci. 2023 Jan 18;24(3):1930. doi: 10.3390/ijms24031930.
5
Microbial and metabolic characterization of organic artisanal sauerkraut fermentation and study of gut health-promoting properties of sauerkraut brine.传统手工制作的有机酸菜发酵过程中的微生物和代谢特征以及酸菜卤水促进肠道健康特性的研究。
Front Microbiol. 2022 Oct 13;13:929738. doi: 10.3389/fmicb.2022.929738. eCollection 2022.
6
A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC.一种叶绿素衍生的叶黄胆素是一种有效的抗氧化剂，可调节人外周血单个核细胞中的免疫代谢。
Antioxidants (Basel). 2022 Oct 19;11(10):2056. doi: 10.3390/antiox11102056.
7
Microfluidic system for immune cell activation and inflammatory cytokine profiling: Application to screening of dietary supplements for anti-inflammatory properties.用于免疫细胞激活和炎性细胞因子分析的微流控系统：在具有抗炎特性的膳食补充剂筛选中的应用。
Biomicrofluidics. 2022 Oct 10;16(5):054105. doi: 10.1063/5.0105187. eCollection 2022 Sep.
8
Development and characterization of a new gill cell line from the striped catfish, Pangasianodon hypophthalmus (Sauvage, 1878).来自低眼无齿𩷶（Pangasianodon hypophthalmus，Sauvage，1878）的一种新鳃细胞系的建立与特性分析
Fish Physiol Biochem. 2022 Apr;48(2):367-380. doi: 10.1007/s10695-022-01053-9. Epub 2022 Feb 15.
9
Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.亲环素A在哮喘大鼠模型及免疫反应抑制中发挥潜在作用。
J Asthma Allergy. 2021 May 7;14:471-480. doi: 10.2147/JAA.S308938. eCollection 2021.
10
NKp30 - A prospective target for new cancer immunotherapy strategies.NKp30 - 一种新的癌症免疫治疗策略的前瞻性靶标。
Br J Pharmacol. 2020 Oct;177(20):4563-4580. doi: 10.1111/bph.15222. Epub 2020 Aug 26.

本文引用的文献

1
Gamma delta T lymphocytosis associated with common variable immunodeficiency.与普通可变免疫缺陷相关的γδT淋巴细胞增多症
J Clin Immunol. 1997 Jan;17(1):34-42. doi: 10.1023/a:1027384311897.
2
Production of T-helper cell subsets and cytokines by lymphocytes from patients with chronic mucocutaneous candidiasis.慢性黏膜皮肤念珠菌病患者淋巴细胞产生的辅助性T细胞亚群和细胞因子
Clin Diagn Lab Immunol. 1996 Nov;3(6):740-5. doi: 10.1128/cdli.3.6.740-745.1996.
3
Type 1 and type 2 cytokine profiles in children exposed to or infected with vertically transmitted human immunodeficiency virus.暴露于或感染垂直传播的人类免疫缺陷病毒的儿童中1型和2型细胞因子谱
Clin Diagn Lab Immunol. 1996 Sep;3(5):493-9. doi: 10.1128/cdli.3.5.493-499.1996.
4
Update on cytokines.细胞因子的最新进展。
J Allergy Clin Immunol. 1996 Mar;97(3):719-33; quiz 734. doi: 10.1016/s0091-6749(96)80146-1.
5
Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases.系统性红斑狼疮、类风湿关节炎及其他风湿性疾病中的细胞因子谱。
J Clin Immunol. 1993 Jan;13(1):58-67. doi: 10.1007/BF00920636.
6
A TH1-->TH2 switch is a critical step in the etiology of HIV infection.辅助性T细胞1（TH1）向辅助性T细胞2（TH2）的转变是HIV感染病因学中的关键一步。
Immunol Today. 1993 Mar;14(3):107-11. doi: 10.1016/0167-5699(93)90208-3.
7
Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression.
J Pediatr. 1995 Mar;126(3):368-74. doi: 10.1016/s0022-3476(95)70450-7.
8
The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures.免疫抑制药物沙利度胺在丝裂原和抗原刺激的人外周血单核细胞培养物中诱导2型辅助性T细胞（Th2），并同时抑制Th1细胞因子的产生。
Clin Exp Immunol. 1995 Feb;99(2):160-7. doi: 10.1111/j.1365-2249.1995.tb05527.x.
9
The Th1-Th2 hypothesis of HIV infection: new insights.HIV感染的Th1-Th2假说：新见解
Immunol Today. 1994 Dec;15(12):575-81. doi: 10.1016/0167-5699(94)90220-8.
10
In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation.正常人外周血单个核细胞的体外细胞因子产生作为免疫能力或激活状态的一种衡量指标。
Clin Diagn Lab Immunol. 1994 May;1(3):261-8. doi: 10.1128/cdli.1.3.261-268.1994.