Andou H, Itoh K, Tsuda T
Department of Internal Medicine, Sin-Beppu Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Oct;35(10):1080-3.
A 73-year-old man with colon cancer had been treated elsewhere for pneumonia on June 12, 1994. He was admitted to our hospital on June 21 with progressive dyspnea and bilateral diffuse infiltrates on chest X-ray. On admission, plain chest radiographs and chest CT scans revealed bilateral interstitial shadows predominantly in the outer zone, of the lower lobes. After an operation for rectal cancer, he had begun taking orally 300 mg of fluorouracil daily for 64 days. A drug lymphocyte stimulation test (DLST) was positive for fluorouracil. Fluorouracil-induced pneumonitis was subsequently diagnosed. To the best of our knowledge, there have been no previous case reports of fluorouracil-induced pneumonitis, and it seems likely that this pneumonitis resulted from both toxic and allergic reactions to the drug.
一名73岁的结肠癌男性患者于1994年6月12日在其他地方接受了肺炎治疗。他于6月21日因进行性呼吸困难和胸部X线显示双侧弥漫性浸润而入住我院。入院时，胸部平片和胸部CT扫描显示双侧间质阴影主要位于下叶外侧区域。直肠癌手术后，他开始每天口服300毫克氟尿嘧啶，共64天。药物淋巴细胞刺激试验（DLST）对氟尿嘧啶呈阳性。随后诊断为氟尿嘧啶诱导的肺炎。据我们所知，此前尚无氟尿嘧啶诱导肺炎的病例报告，这种肺炎似乎是由对该药物的毒性和过敏反应共同引起的。
