质量控制措施未能防止对亚胺培南的假耐药报告，导致耐亚胺培南铜绿假单胞菌的假性暴发。
Failure of quality control measures to prevent reporting of false resistance to imipenem, resulting in a pseudo-outbreak of imipenem-resistant Pseudomonas aeruginosa.
作者信息
Carmeli Y, Eichelberger K, Soja D, Dakos J, Venkataraman L, DeGirolami P, Samore M
机构信息
Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
出版信息
J Clin Microbiol. 1998 Feb;36(2):595-7. doi: 10.1128/JCM.36.2.595-597.1998.
Abstract
False results showing an outbreak of Pseudomonas aeruginosa with resistance to imipenem were traced to a defective lot of microdilution MIC testing panels. These panels contained two- to threefold lower concentrations of imipenem than expected and resulted in artifactual two- to fourfold increases in MICs of imipenem. The quality-control MIC results for Pseudomonas aeruginosa ATCC 27853 were 4 microg/ml, the highest value within the range recommended by the National Committee for Clinical Laboratory Standards. We recommend that this value be considered out of the quality-control range.
摘要
显示对亚胺培南耐药的铜绿假单胞菌暴发的错误结果，被追溯到一批有缺陷的微量稀释法最低抑菌浓度（MIC）检测板。这些检测板中亚胺培南的浓度比预期低两到三倍，导致亚胺培南的MIC出现人为的两到四倍升高。铜绿假单胞菌ATCC 27853的质量控制MIC结果为4微克/毫升，这是美国国家临床实验室标准委员会推荐范围内的最高值。我们建议将该值视为超出质量控制范围。
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J Clin Microbiol. 1994 Oct;32(10):2584-7. doi: 10.1128/jcm.32.10.2584-2587.1994.
6
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7
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