使用微量稀释药敏试验系统时对亚胺培南的假耐药性。
False resistance to imipenem with a microdilution susceptibility testing system.
作者信息
O'Rourke E J, Lambert K G, Parsonnet K C, Macone A B, Goldmann D A
机构信息
Division of Infectious Diseases, Children's Hospital, Boston, Massachusetts.
出版信息
J Clin Microbiol. 1991 Apr;29(4):827-9. doi: 10.1128/jcm.29.4.827-829.1991.
Abstract
Routine monitoring of antibiotic resistance at Children's Hospital, Boston, detected a dramatic increase in the prevalence of imipenem-resistant strains of Pseudomonas aeruginosa. Further studies documented that false resistance to imipenem was due, in part, to the loss of imipenem potency in customized MIC microdilution trays supplied by Sensititre Ltd. (West Sussex, United Kingdom). Recognition of the problem was delayed by use of the quality control standard recommended by the manufacturer, which were higher and broader than those suggested by the National Committee for Clinical Laboratory Standards.
摘要
波士顿儿童医院对抗生素耐药性的常规监测发现，铜绿假单胞菌对亚胺培南耐药菌株的流行率急剧上升。进一步研究表明，对亚胺培南的假耐药性部分归因于Sensititre有限公司（英国西苏塞克斯）提供的定制微量肉汤稀释药敏板中亚胺培南效力的丧失。由于使用了制造商推荐的质量控制标准，该问题的识别被延迟，制造商推荐的标准比美国国家临床实验室标准委员会建议的标准更高、范围更广。
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本文引用的文献
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Determination of imipenem (N-formimidoyl thienamycin) in human plasma and urine by high-performance liquid chromatography, comparison with microbiological methodology and stability.用高效液相色谱法测定人血浆和尿液中的亚胺培南（N-甲酰亚胺硫霉素），与微生物学方法比较及稳定性研究
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Quality control limits for microdilution susceptibility tests with aztreonam, imipenem, ceftriaxone, ceftazidime, ceftizoxime, cefuroxime, and cefonicid.氨曲南、亚胺培南、头孢曲松、头孢他啶、头孢唑肟、头孢呋辛和头孢尼西微稀释药敏试验的质量控制限度
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