Ganz P A, Rowland J H, Desmond K, Meyerowitz B E, Wyatt G E
University of California, Los Angeles, School of Medicine, Jonsson Comprehensive Cancer Center, 90024, USA.
J Clin Oncol. 1998 Feb;16(2):501-14. doi: 10.1200/JCO.1998.16.2.501.
To describe the health-related quality of life (HRQL), partner relationships, sexual functioning, and body image concerns of breast cancer survivors (BCS) in relation to age, menopausal status, and type of cancer treatment.
A cross-sectional sample of BCS in two large metropolitan areas was invited to participate in a survey study that included the following standardized measures: the RAND 36-Item Health Survey; the Centers for Epidemiologic Studies-Depression Scale (CES-D); the Dyadic Adjustment Scale (DAS); the Breast Cancer Prevention Trial (BCPT) Symptom Checklist; the Watts Sexual Functioning Questionnaire (WSFQ); and subscales from the Cancer Rehabilitation Evaluation System (CARES).
Eight hundred sixty-four BCS completed the survey. RAND Health Survey scores were as good or better than those of healthy, age-matched women, and the frequency of depression was similar to general population samples. Marital/partner adjustment was similar to normal healthy samples, and sexual functioning mirrored that of healthy, age-matched postmenopausal women. However, these BCS reported higher rates of physical symptoms (eg, joint pains, headaches, and hot flashes) than healthy women. Sexual dysfunction occurred more frequently in women who had received chemotherapy (all ages), and in younger women who were no longer menstruating. In women > or = 50 years, tamoxifen therapy was unrelated to sexual functioning.
BCS report more frequent physical and menopausal symptoms than healthy women, yet report HRQL and sexual functioning comparable to that of healthy, age-matched women. Nevertheless, some survivors still experience poorer functioning, and clinicians should inquire about common symptoms to provide symptomatic management or counseling for these women.
描述乳腺癌幸存者（BCS）与年龄、绝经状态及癌症治疗类型相关的健康相关生活质量（HRQL）、伴侣关系、性功能和身体形象问题。
邀请两个大城市地区的BCS横断面样本参与一项调查研究，该研究包括以下标准化测量：兰德36项健康调查；流行病学研究中心抑郁量表（CES-D）；二元调整量表（DAS）；乳腺癌预防试验（BCPT）症状清单；瓦茨性功能问卷（WSFQ）；以及癌症康复评估系统（CARES）的子量表。
864名BCS完成了调查。兰德健康调查得分与年龄匹配的健康女性相当或更好，抑郁发生率与一般人群样本相似。婚姻/伴侣关系调整与正常健康样本相似，性功能与年龄匹配的绝经后健康女性相似。然而，这些BCS报告的身体症状（如关节疼痛、头痛和潮热）发生率高于健康女性。性功能障碍在接受化疗的女性（各年龄段）以及不再月经的年轻女性中更常见。在年龄≥50岁的女性中，他莫昔芬治疗与性功能无关。
BCS报告的身体和绝经症状比健康女性更频繁，但报告的HRQL和性功能与年龄匹配的健康女性相当。尽管如此，一些幸存者仍存在功能较差的情况，临床医生应询问常见症状，为这些女性提供症状管理或咨询。
