Berk R N, Loeb P M, Cobo-Frenkel A, Barnhart J L
Radiology. 1976 Jun;119(3):529-36. doi: 10.1148/119.3.529.
The biliary excretion and choleretic effects of iodoxamate (Cholevue) and iodipamide (Cholografin) were compared in unanesthetized dogs with biliary fistulas in order to assess the potential of the two contrast agents for use in intravenous cholangiography. For any equimolar infusion rate, more iodoxamate was secreted in the bile than iodipamide was the same. At the constant basal bile flow maintained in these studies, there was no difference in the maximum biliary concentration of the two compounds. With the presently recommended doses, it is unlikely that iodoxamate will offer a striking improvement over iodipamide for intravenous cholangiography in patients with normal liver function.
为了评估两种造影剂用于静脉胆管造影的潜力，在未麻醉的、有胆瘘的犬中比较了碘多啥（胆影葡胺）和碘番酸（碘肥酸）的胆汁排泄及利胆作用。对于任何等摩尔输注速率，胆汁中分泌的碘多啥比相同情况下的碘番酸更多。在这些研究中维持的恒定基础胆汁流量下，两种化合物的最大胆汁浓度没有差异。以目前推荐的剂量，对于肝功能正常的患者，碘多啥在静脉胆管造影方面不太可能比碘番酸有显著改善。
