Burgener F A, Fischer H W
Invest Radiol. 1979 Nov-Dec;14(6):502-7. doi: 10.1097/00004424-197911000-00010.
Iodipamide and iodoxamate were compared in equimolar clinical dosages in five cholecystectomized chronic bile fistula dogs in which hepatic dysfunction was produced by oral administration of a total dose of 480 and 960 microliters dimethylnitrosamine (DMNA), respectively. After both DMNA dosages, the peak biliary excretion rate for iodoxamate was significantly higher than for iodipamide (p less than 0.01). The peak bile iodine concentration was not significantly different for the two agents (480 microliter DMNA: p less than 0.1; 960 microliter DMNA: p = 0.07). On the basis of this investigation, it is suggested that iodoxamate should not significantly improve the opacification of the biliary system in patients with hepatic dysfunction.
在五只因口服总量分别为480微升和960微升二甲基亚硝胺（DMNA）而导致肝功能障碍的胆囊切除慢性胆瘘犬中，对碘番酸和碘多啥以等摩尔临床剂量进行了比较。在两种DMNA剂量给药后，碘多啥的胆汁排泄峰值率显著高于碘番酸（p＜0.01）。两种药物的胆汁碘浓度峰值无显著差异（480微升DMNA：p＜0.1；960微升DMNA：p = 0.07）。基于这项研究，提示碘多啥对肝功能障碍患者的胆道系统显影改善作用不显著。
