Burgener F A, Fischer H W, Denyon T D
Invest Radiol. 1978 May-Jun;13(3):255-63. doi: 10.1097/00004424-197805000-00013.
Iodipamide and iodoxamate were compared at equimolar clinical dosages in dogs with normal, incompletely obstructed and completely obstructed common bile ducts. Forty-eight experiments were performed under general anesthesia in six cholecystomized chronic bile fistula dogs. The peak biliary iodoxamate excretion rate, but not the peak bile iodoxamate concentration, was significantly higher with normal and incompletely obstructed common bile ducts. In complete obstruction, both a significantly higher total biliary iodoxamate excretion and concentration were obtained, but this was still insufficient for radiographic opacification by conventional technique. Lesser toxicity of iodoxamate is suggested by its significantly lower serum levels, its higher bile: urine excretion ratio and its faster compensatory urinary excretion in complete common bile duct obstruction. Iodoxamate appears on this evidence to be a better cholangiographic contrast agent than iodipamide.
在胆总管正常、不完全梗阻和完全梗阻的犬中，以等摩尔临床剂量对碘番酸和碘多啥胺进行了比较。在6只胆囊切除的慢性胆瘘犬中，于全身麻醉下进行了48项实验。胆总管正常和不完全梗阻时，胆汁中碘多啥胺的排泄率峰值显著更高，但胆汁中碘多啥胺的浓度峰值并非如此。在完全梗阻时，胆汁中碘多啥胺的总排泄量和浓度均显著更高，但这仍不足以通过传统技术实现造影剂显影。碘多啥胺的血清水平显著更低、胆汁与尿液排泄比更高以及在胆总管完全梗阻时其代偿性尿液排泄更快，提示其毒性较小。基于这些证据，碘多啥胺似乎是一种比碘番酸更好的胆管造影剂。
