Jedrychowski W, Flak E, Mróz E
Katedry Epidemiologii i Medycyny, Zapobiegawczej Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Pneumonol Alergol Pol. 1997;65(9-10):605-10.
The paper examines the relation of maternal smoking during pregnancy and lung function of 1029 schoolchildren aged 9 years. Children from Cracow whose mothers had smoked during pregnancy had significantly lower lung function than the children whose mothers had not smoked in this period. On average, spirometric data of FEV1/FVC, FEF25-75% and PEFR were 1.1%, 4.7%, and 3.2% lower respectively, in those children whose mothers had smoked during pregnancy. The effect was statistically significant after accounting for potential confounders such as current smoking habit of parents. The results provide a new support for the hypothesis that deficit in lung function among children is associated with maternal smoking in pregnancy. The strongest effects were found to involve the function of small airways.
该论文研究了1029名9岁学童的母亲孕期吸烟与肺功能之间的关系。来自克拉科夫的儿童中,母亲在孕期吸烟的孩子,其肺功能明显低于母亲在此期间不吸烟的孩子。平均而言,母亲孕期吸烟的孩子,其第一秒用力呼气容积/用力肺活量(FEV1/FVC)、25%~75%用力呼气流量(FEF25-75%)和呼气峰值流速(PEFR)的肺量计数据分别低1.1%、4.7%和3.2%。在考虑了诸如父母当前吸烟习惯等潜在混杂因素后,该效应具有统计学意义。这些结果为儿童肺功能缺陷与母亲孕期吸烟有关这一假设提供了新的支持。研究发现,对小气道功能的影响最为显著。