Jenne L, Kilwinski J, Radloff P, Flick W, Kern P
Section of Infectious Diseases and Clinical Immunology, University Hospital and Medical Clinic of Ulm, Germany.
Clin Infect Dis. 1998 Feb;26(2):492-4. doi: 10.1086/516316.
Alveolar echinococcosis (AE) is a rare and often fatal disease characterized by a tumorlike expansion of the metacestode Echinococcus multilocularis in the liver. Because of the severe side effects of therapy with benzimidazoles, we treated a patient with recombinant interferon gamma at a dose of 250 microg over a 3-day period once a month. Disease progression was not detected during the observed period of 18 months. Following stimulation with crude Echinococcus antigen, mRNA from interleukin 5 was still detected in peripheral blood mononuclear cells by means of reverse transcriptase polymerase chain reaction analysis, and expression of interleukin 10 in T lymphocytes (as measured by fluorescence-associated cell sorting of intracellular cytokines) was elevated. These results indicate that bolus therapy with interferon gamma has some clinical effect but does not result in a change in the T helper 2 lymphocyte-dominated immune response to this parasite.
肺泡型包虫病（AE）是一种罕见且常致命的疾病，其特征为多房棘球绦虫的原头蚴在肝脏呈肿瘤样扩张。由于苯并咪唑类治疗存在严重副作用，我们对一名患者每月一次，连续3天给予剂量为250微克的重组干扰素γ进行治疗。在观察的18个月期间未检测到疾病进展。用棘球绦虫粗抗原刺激后，通过逆转录聚合酶链反应分析在外周血单个核细胞中仍能检测到白细胞介素5的mRNA，且T淋巴细胞中白细胞介素10的表达（通过细胞内细胞因子的荧光相关细胞分选测定）升高。这些结果表明，干扰素γ推注疗法具有一定临床效果，但并未改变针对该寄生虫的以辅助性T细胞2淋巴细胞为主导的免疫反应。
