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肺泡型棘球蚴病患者的寄生虫特异性IL-17型细胞因子反应及可溶性IL-17受体水平

Parasite-specific IL-17-type cytokine responses and soluble IL-17 receptor levels in Alveolar Echinococcosis patients.

作者信息

Lechner Christian J, Grüner Beate, Huang Xiangsheng, Hoffmann Wolfgang H, Kern Peter, Soboslay Peter T

机构信息

Institute for Tropical Medicine, University of Tübingen Clinics, 72074 Tübingen, Germany.

出版信息

Clin Dev Immunol. 2012;2012:735342. doi: 10.1155/2012/735342. Epub 2012 Aug 30.

DOI:10.1155/2012/735342
PMID:22969818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437316/
Abstract

Alveolar Echinococcosis (AE) caused by the cestode Echinococcus multilocularis, is a severe helminth infection of man, where unrestricted parasite growth will ultimately result in organ failure and fatality. The tissue-infiltrative growth of the larval metacestode and the limited efficacy of available drugs complicate successful intervention in AE; patients often need life-long medication, and if possible, surgical resection of affected tissues and organs. Resistance to AE has been reported, but the determinants which confer protection are not known. ln this study, we analyzed in patients at distinct stages of Alveolar Echirococcosis, that is cured, stable and progressive AE, as well as in infection-free controls, the cellular production and plasma levels of pro-inflammatory cytokines lL-17A, lL-17B, lL-17F and their soluble receptors lL-17RA (slL-17RA) and IL-17RB (sIL-17RB). Significantly elevated levels of IL-17B and slL-17RB were observed, whilst lL-17F and slL-17RA were reduced in patients with AE. Similarly, the cellular production of lL-17F and slL-L7RA in response to E. multilocularis antigens was low in AE patients, while levels of slL-17RB were highly enhanced. These observations suggest immune-modulating properties of E. multitocularis on lL-17 cytokine-mediated pro-inflammatory immune responses; this may facilitate the tissue infiltrative growth of the parasite and its persistence in the human host.

摘要

由多房棘球绦虫引起的肺泡型棘球蚴病（AE）是一种严重的人体蠕虫感染疾病，寄生虫不受限制的生长最终将导致器官衰竭和死亡。幼虫型原头蚴的组织浸润性生长以及现有药物疗效有限，使得AE的成功干预变得复杂；患者通常需要终身服药，若有可能，还需对受影响的组织和器官进行手术切除。已有对AE产生抗性的报道，但赋予保护作用的决定因素尚不清楚。在本研究中，我们分析了处于肺泡型棘球蚴病不同阶段（即已治愈、病情稳定和病情进展期的AE）的患者以及未感染对照组中促炎细胞因子IL-17A、IL-17B、IL-17F及其可溶性受体IL-17RA（sIL-17RA）和IL-17RB（sIL-17RB）的细胞产生量和血浆水平。观察到AE患者中IL-17B和sIL-17RB水平显著升高，而IL-17F和sIL-17RA水平降低。同样，AE患者对多房棘球绦虫抗原产生的IL-17F和sIL-17RA细胞产量较低，而sIL-17RB水平则显著升高。这些观察结果表明多房棘球绦虫对IL-17细胞因子介导炎性免疫反应具有免疫调节特性；这可能有助于寄生虫的组织浸润性生长及其在人类宿主中的持续存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/8c7294f9be22/CDI2012-735342.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/e4cf6c1a48e3/CDI2012-735342.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/18ebfbb9dbf0/CDI2012-735342.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/0056ce1a66ac/CDI2012-735342.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/da9630a7a403/CDI2012-735342.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/8c7294f9be22/CDI2012-735342.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/e4cf6c1a48e3/CDI2012-735342.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/18ebfbb9dbf0/CDI2012-735342.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/0056ce1a66ac/CDI2012-735342.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/da9630a7a403/CDI2012-735342.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a09/3437316/8c7294f9be22/CDI2012-735342.005.jpg

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