Marriott Marie, Holmes Jo, Peters Lisa, Cooper Karen, Rowson Matthew, Basketter David A
Safety and Environmental Assurance Centre, Unilever Colworth Laboratory, Sharnbrook, Bedford, MK44 1LQ, UK.
Contact Dermatitis. 2005 Aug;53(2):93-9. doi: 10.1111/j.0105-1873.2005.00653.x.
There exists within the population subsets of individuals who display heightened skin reactivity to materials the majority find tolerable. In a series of investigations, we have examined interrelationships between many of the endpoints associated with the term 'sensitive skin'. In the most recent work, 58 volunteers were treated with 10% lactic acid, 50% ethanol, 0.5% menthol and 1.0% capsaicin on the nasolabial fold, unoccluded, with sensory reactions recorded at 2.5 min, 5 min and 8 min after application. Urticant susceptibility was evaluated with 1 m benzoic acid and 125 mM trans-cinnamic acid applied to the volar forearm for 20 min. A 2 x 23-h patch test was also conducted using 0.1% and 0.3% sodium dodecyl sulfate, 0.3% and 0.6% cocamidopropyl betaine and 0.1% and 0.2% benzalkonium chloride to determine irritant susceptibility. As found in previous studies, increased susceptibility to one endpoint was not predictive of sensitivity to another. In our experience, nasolabial stinging was a poor predictor of general skin sensitivity. Nevertheless, it may be possible to identify in the normal population individuals who, coincidentally, are more generally sensitive to a range of non-immunologic adverse skin reactions. Whether such individuals are those who experience problems with skin care products remains to be addressed.
人群中存在一部分个体亚群，他们对大多数人可耐受的物质表现出皮肤反应性增强。在一系列研究中，我们研究了与“敏感性皮肤”这一术语相关的许多终点之间的相互关系。在最近的一项研究中，58名志愿者在鼻唇沟处涂抹10%乳酸、50%乙醇、0.5%薄荷醇和1.0%辣椒素，不封闭，在涂抹后2.5分钟、5分钟和8分钟记录感觉反应。用1 m苯甲酸和125 mM反式肉桂酸涂抹在前臂掌侧20分钟来评估荨麻疹易感性。还进行了一项2×23小时的斑贴试验，使用0.1%和0.3%的十二烷基硫酸钠、0.3%和0.6%的椰油酰胺丙基甜菜碱以及0.1%和0.2%的苯扎氯铵来确定刺激易感性。正如之前的研究所发现的，对一个终点的易感性增加并不能预测对另一个终点的敏感性。根据我们的经验，鼻唇沟刺痛对一般皮肤敏感性的预测性较差。然而，有可能在正常人群中识别出那些碰巧对一系列非免疫性皮肤不良反应更敏感的个体。这些个体是否就是那些在护肤品使用方面存在问题的人还有待探讨。
