Lammintausta K, Maibach H I, Wilson D
Department of Dermatology, San Francisco Medical Center, University of California.
Derm Beruf Umwelt. 1988 Mar-Apr;36(2):45-9.
Subjective (sensory) irritation was studied with lactic acid test on 74 females; 8 reacted positively with "stinging" and/or itching or burning and another 5 had mild subjective sensations. History of previous corresponding sensations from contact with cosmetic products was significantly more common in stingers than in non-stingers (p less than 0.001); other factors, such as dermatologic history, sensitivity to ultraviolet light or skin dryness had no characteristic patterns. In the objective, immediate non-immunologic contact urticaria tests with sorbic acid and benzoic acid, the stingers developed significantly more erythema to 0.5% sorbic acid (p less than 0.05) and to 1% benzoic acid (p less than 0.02). 1% sorbic acid also induced more edema in stingers (p less than 0.02). Increased reactivity to a 24 h sodium lauryl sulfate (SLS) patch test was demonstrated only with laser Doppler velocimetry (p less than 0.05). Stingers and non-stingers reacted similarly to open, cumulative SLS irritation as measured with transepidermal water loss. These studies provide clinical and biological information about subjective irritation; the data suggest a functional correlation for the what had been considered a purely subjective (sensory) phenomena.
通过乳酸试验对74名女性进行了主观（感觉）刺激研究；8人对“刺痛”和/或瘙痒或灼烧有阳性反应，另外5人有轻微的主观感觉。有使用化妆品产生相应感觉既往史的刺痛者比无刺痛者更常见（p<0.001）；其他因素，如皮肤病史、对紫外线的敏感性或皮肤干燥情况，无特征性模式。在使用山梨酸和苯甲酸进行的客观即时非免疫性接触性荨麻疹试验中，刺痛者对0.5%山梨酸（p<0.05）和1%苯甲酸（p<0.02）产生的红斑明显更多。1%山梨酸在刺痛者中也引起更多水肿（p<0.02）。仅通过激光多普勒测速仪证实，对24小时十二烷基硫酸钠（SLS）斑贴试验的反应性增加（p<0.05）。按照经表皮水分流失测量，刺痛者和无刺痛者对开放性累积SLS刺激的反应相似。这些研究提供了关于主观刺激的临床和生物学信息；数据表明，对于曾被认为是纯粹主观（感觉）现象的情况存在功能相关性。
