在俄罗斯圣彼得堡发现的一株鼠伤寒沙门氏菌克隆中，一种介导对头孢噻肟耐药性的质粒介导的β-内酰胺酶。
A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia.
作者信息
Gazouli M, Sidorenko S V, Tzelepi E, Kozlova N S, Gladin D P, Tzouvelekis L S
机构信息
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
出版信息
J Antimicrob Chemother. 1998 Jan;41(1):119-21. doi: 10.1093/jac/41.1.119.
PMID:9511047
Abstract
Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.
摘要
对在俄罗斯圣彼得堡收集的4株临床分离和2株环境分离的耐头孢噻肟鼠伤寒沙门氏菌菌株进行了研究。分子分型表明它们构成了一个单一克隆。这些分离株表达一种pH值为8.4的头孢噻肟水解β-内酰胺酶。该酶由一个12 kb的质粒编码，该质粒不与TEM、SHV或ampC探针杂交。
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