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Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii.

作者信息

Sgarbi D B, da Silva A J, Carlos I Z, Silva C L, Angluster J, Alviano C S

机构信息

Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, RJ.

出版信息

Mycopathologia. 1997;139(1):9-14. doi: 10.1023/a:1006803832164.

DOI:10.1023/a:1006803832164
PMID:9511231
Abstract

Ergosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.

摘要

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