Kriegsman D M, Deeg D J, van Eijk J T, Penninx B W, Boeke A J
Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
J Epidemiol Community Health. 1997 Dec;51(6):676-85. doi: 10.1136/jech.51.6.676.
To determine whether disease specific characteristics, reflecting clinical disease severity, add to the explanation of mobility limitations in patients with specific chronic diseases.
Cross sectional study of survey data from community dwelling elderly people, aged 55-85 years, in the Netherlands.
The additional explanation of mobility limitations by disease specific characteristics was examined by logistic regression analyses on data from 2830 community dwelling elderly people.
In the total sample, chronic non-specific lung disease, cardiac disease, peripheral atherosclerosis, diabetes mellitus, stroke, arthritis and cancer (the index diseases), were all independently associated with mobility limitations. Adjusted for age, sex, comorbidity, and medical treatment disease specific characteristics that explain the association between disease and mobility mostly reflect decreased endurance capacity (shortness of breath and disturbed night rest in chronic non-specific lung disease, angina pectoris and congestive heart failure in cardiac disease), or are directly related to mobility function (stiffness and lower body complaints in arthritis). For atherosclerosis and diabetes mellitus, disease specific characteristics did not add to the explanation of mobility limitations.
The results provide evidence that, to obtain more detailed information about the differential impact of chronic diseases on mobility, disease specific characteristics are important to take into account.
确定反映临床疾病严重程度的疾病特异性特征是否有助于解释特定慢性病患者的活动受限情况。
对荷兰55 - 85岁社区居住老年人的调查数据进行横断面研究。
通过对2830名社区居住老年人的数据进行逻辑回归分析，研究疾病特异性特征对活动受限的额外解释作用。
在总样本中，慢性非特异性肺病、心脏病、外周动脉粥样硬化、糖尿病、中风、关节炎和癌症（指标疾病）均与活动受限独立相关。在调整年龄、性别、合并症和医疗治疗因素后，解释疾病与活动受限之间关联的疾病特异性特征大多反映了耐力下降（慢性非特异性肺病中的呼吸急促和夜间休息受扰、心脏病中的心绞痛和充血性心力衰竭），或与活动功能直接相关（关节炎中的僵硬和下身不适）。对于动脉粥样硬化和糖尿病，疾病特异性特征并未增加对活动受限的解释。
结果表明，为了获得关于慢性病对活动影响差异的更详细信息，考虑疾病特异性特征很重要。
