Ece A, Uyanik B S, Işcan A, Ertan P, Yiğitoğlu M R
Celal Bayar University, Faculty of Medicine, Department of Pediatrics, Manisa, Turkey.
Biol Trace Elem Res. 1997 Winter;59(1-3):31-9. doi: 10.1007/BF02783227.
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged 1-14 yr and 64 healthy children as controls aged 1-14 yr were included the study. Serum copper levels were higher in children with IDA (189 +/- 49 micrograms/dL) than those of controls (163 +/- 37 micrograms/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 +/- 59 micrograms/dL) than those of control subjects (135 +/- 56 micrograms/dL) (p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum zinc level in patients. It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment should be initiated with zinc.
为了评估缺铁性贫血（IDA）患儿的血清铜和锌水平，本研究纳入了60名1 - 14岁的IDA患儿以及64名1 - 14岁的健康儿童作为对照。IDA患儿的血清铜水平（189±49微克/分升）高于对照组（163±37微克/分升）（p = 0.001）。患者组的血清锌水平（109±59微克/分升）低于对照组（135±56微克/分升）（p = 0.017）。此外，患者组血液学参数与血清铜水平之间存在统计学显著的负相关，而对照组则无。除了患者组中平均红细胞体积（MCV）与血清锌水平呈正相关外，患者组和对照组的血液学参数与血清锌水平之间均未发现相关性。研究得出结论，在管理IDA患儿时，必须牢记锌缺乏情况，如有必要应开始补锌治疗。
