Zamoyska R
National Institute for Medical Research, London, UK.
Curr Opin Immunol. 1998 Feb;10(1):82-7. doi: 10.1016/s0952-7915(98)80036-8.
The response of T cells to antigen involves the participation of a number of distinct receptor-ligand engagements. The major players in the recognition of complexes of major histocompatibility complex molecules and peptide antigens are the T-cell receptors and the co-receptors CD4 and CD8. Progress in understanding the physical structures of these molecules, and how complexes between them are formed, is helping our understanding of how they participate in regulating the signals transduced to T cells.
T细胞对抗原的反应涉及许多不同的受体-配体相互作用。识别主要组织相容性复合体分子与肽抗原复合物的主要参与者是T细胞受体以及共受体CD4和CD8。在了解这些分子的物理结构以及它们之间的复合物如何形成方面所取得的进展，正有助于我们理解它们如何参与调节转导至T细胞的信号。
