Rynkiewicz D L, Cage G D, Butler W R, Ampel N M
Infectious Diseases Section, University of Arizona College of Medicine, Tucson, USA.
Clin Infect Dis. 1998 Mar;26(3):625-30. doi: 10.1086/514573.
Mycobacterium simiae was the third most common mycobacterium identified over a 2-year period from a single clinical laboratory in southern Arizona. Thirty-three isolates from 25 patients were identified over 1 year. The isolation of M. simiae was considered clinically significant for only two of 23 evaluable patients. None of five patients with human immunodeficiency virus infection had clinical disease associated with M. simiae. Twenty isolates were available for detailed study. All but one of the 20 isolates were niacin-negative, and 11 were nonphotochromogenic. All 20 isolates had a triple-cluster pattern consistent with M. simiae by high-performance liquid chromatography, and restriction fragment patterns were identical for 16 isolates. Analysis of 16S rDNA confirmed the identity of all the tested isolates as M. simiae. In this study, M. simiae was a frequent clinical isolate but was rarely associated with disease. The organisms isolated were confirmed to be M. simiae but appeared to be phenotypically distinct strains of low virulence.
在亚利桑那州南部的一个临床实验室，在两年时间里，猿分枝杆菌是第三常见的分枝杆菌。在1年时间里，从25名患者中鉴定出33株分离菌。对于23名可评估患者中的仅两名，猿分枝杆菌的分离被认为具有临床意义。5名人类免疫缺陷病毒感染患者中，没有一人患有与猿分枝杆菌相关的临床疾病。有20株分离菌可用于详细研究。20株分离菌中除1株外均烟酸阴性，11株为非光产色菌。通过高效液相色谱法，所有20株分离菌均具有与猿分枝杆菌一致的三聚体模式，16株分离菌的限制性片段模式相同。16S rDNA分析证实所有测试分离菌均为猿分枝杆菌。在本研究中，猿分枝杆菌是常见的临床分离菌，但很少与疾病相关。分离出的菌株经证实为猿分枝杆菌，但似乎是低毒力的表型不同菌株。
