新型7-取代氟喹诺酮类药物Y-688对厌氧菌的体外活性
In vitro activities of Y-688, a new 7-substituted fluoroquinolone, against anaerobic bacteria.
作者信息
MacGowan A P, Bowker K E, Wootton M, Holt H A, Reeves D S
机构信息
Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1998 Feb;42(2):419-24. doi: 10.1128/AAC.42.2.419.
Abstract
The in vitro activities of Y-688, a new 7-substituted fluoroquinolone derivative, against 317 nonduplicate anaerobic isolates were determined. Eighty-five percent of the Bacteroides fragilis group (n = 89) were inhibited by < or = 2 mg of Y-688 per liter, while 78, 100, 89, and 98% of gram-negative bacilli (n = 135), gram-positive cocci (n = 59), and non-spore-forming (n = 58) and spore-forming (n = 51) gram-positive bacilli, respectively, were inhibited by < or = 1 mg of Y-688 per liter.
摘要
测定了新型7-取代氟喹诺酮衍生物Y-688对317株非重复厌氧分离株的体外活性。每升含≤2毫克Y-688时，85%的脆弱拟杆菌群（n = 89）受到抑制，而每升含≤1毫克Y-688时，分别有78%的革兰氏阴性杆菌（n = 135）、100%的革兰氏阳性球菌（n = 59）、89%的无芽孢革兰氏阳性杆菌（n = 58）和98%的芽孢革兰氏阳性杆菌（n = 51）受到抑制。
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