1型糖尿病中的IgG抗内皮细胞抗体（AECA）；培养的内皮细胞中黏附分子表达的诱导
IgG anti-endothelial cell antibodies (AECA) in type I diabetes mellitus; induction of adhesion molecule expression in cultured endothelial cells.
作者信息
Triolo G, Triolo G, Accardo-Palumbo A, Carbone M C, Ferrante A, Casiglia D, Giardina E
机构信息
Department of Internal Medicine, University of Palermo, Italy.
出版信息
Clin Exp Immunol. 1998 Mar;111(3):491-6. doi: 10.1046/j.1365-2249.1998.00524.x.
AECA were detected in 25 of 71 patients with type 1 diabetes mellitus and in two of 33 healthy subjects. Patients with diabetes of < 1 year duration and those with long-standing disease had the highest levels of these antibodies. Inhibition studies suggest that at least part of the AECA reactivity is due to cross-reactive anti-ssDNA antibodies. AECA-positive sera were able to increase intercellular adhesion molecule-1 (ICAM-1) and E-selectin on human umbilical vein endothelial cells (HUVEC). Increased binding of polymorphonuclear (PMN) cells was also found to accompany raised E-selectin expression. Soluble ICAM-1 and E-selectin were also found to be increased in the sera of AECA-positive patients. An effect of AECA on endothelial cell function is suggested in diabetes mellitus.
在71例1型糖尿病患者中，有25例检测到抗内皮细胞抗体（AECA），而在33名健康受试者中，有2例检测到该抗体。病程小于1年的糖尿病患者和长期患病的患者体内这些抗体水平最高。抑制研究表明，AECA反应性至少部分归因于交叉反应性抗单链DNA抗体。AECA阳性血清能够增加人脐静脉内皮细胞（HUVEC）上的细胞间黏附分子-1（ICAM-1）和E-选择素。还发现多形核（PMN）细胞结合增加与E-选择素表达升高相伴。在AECA阳性患者的血清中也发现可溶性ICAM-1和E-选择素增加。提示AECA对糖尿病患者的内皮细胞功能有影响。
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