蜱免疫豚鼠中的粒细胞埃立克体病
Granulocytic ehrlichiosis in tick-immune guinea pigs.
作者信息
Das S, Deponte K, Marcantonio N L, Ijdo J W, Hodzic E, Katavolos P, Barthold S W, Telford S R, Kantor F S, Fikrig E
机构信息
Department of Internal Medicine, Yale University, New Haven, Connecticut 06520-8031, USA.
出版信息
Infect Immun. 1998 Apr;66(4):1803-5. doi: 10.1128/IAI.66.4.1803-1805.1998.
Abstract
We investigated whether Ixodes scapularis-mediated host immunity interrupts transmission of the agent of human granulocytic ehrlichiosis (aoHGE) to guinea pigs. Ticks infected with aoHGE readily transmitted aoHGE to tick-immune guinea pigs, despite incomplete tick engorgement and host attachment. Although tick immunity can prevent Lyme borreliosis, protection is not afforded against granulocytic ehrlichiosis.
摘要
我们研究了肩突硬蜱介导的宿主免疫是否会中断人粒细胞埃立克体病病原体（aoHGE）向豚鼠的传播。尽管蜱虫未完全饱血且未牢固附着在宿主体上，但感染了aoHGE的蜱虫仍能轻易地将aoHGE传播给对蜱虫免疫的豚鼠。虽然蜱虫免疫可以预防莱姆病，但对粒细胞埃立克体病却没有防护作用。
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本文引用的文献
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2
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3
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J Infect Dis. 1997 Sep;176(3):687-92. doi: 10.1086/514091.
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