de Cock J, Heederik D, Kromhout H, Boleij J S, Hoek F, Wegh H, Tjoe Ny E
Department of Epidemiology and Public Health, University of Wageningen, The Netherlands.
Am Ind Hyg Assoc J. 1998 Mar;59(3):158-65. doi: 10.1080/15428119891010415.
This study characterized occupational exposure to pesticides in fruit growing in The Netherlands to assess determinants of exposure. Large-scale exposure surveys were carried out during application of pesticides and during reentry activities. Data on contamination inside the fruit growers' homes were obtained, and total potential exposure for the fruit grower and his family during the growing and harvesting season was estimated. Repeated measurements on the same subject were collected to study components of exposure variability. Relative contribution of the respiratory route and different skin sites to total exposure were assessed. Captan was used as a marker for exposure. Inhalable dust exposure was measured with a personal monitor and potential dermal exposure with skin pads and hand rinsing. Dislodgeable foliar residue was measured by taking leaf punches. For respiratory exposure and potential dermal exposure, differences were observed between several tasks. Workers were categorized according to tasks performed depending on the exposure measure(s) (e.g., hands, forehead, inhalable dust) considered relevant for a specific study purpose. In general, within-worker variability of all exposure measurements was larger than between-worker variability. Variability in dermal exposure on the same body location was small relative to variability between different body locations. Differences in total exposure, including exposure inside the home, between the fruit grower and the son were small. Exposure of the wife was two to three times lower than for the fruit grower and the son. As exposure per unit of time was in the same order of magnitude for different tasks, individual time spent on these tasks is crucial for estimating total potential exposure. Repeated measurements are necessary to estimate individual exposure accurately because of the large within-worker variability.
本研究对荷兰水果种植中农药的职业暴露进行了特征描述,以评估暴露的决定因素。在农药施用期间和重新进入作业期间开展了大规模暴露调查。获取了水果种植者家中污染的数据,并估算了水果种植者及其家人在生长和收获季节的总潜在暴露量。收集了对同一受试者的重复测量数据,以研究暴露变异性的组成部分。评估了呼吸道途径和不同皮肤部位对总暴露的相对贡献。克菌丹用作暴露的标志物。可吸入粉尘暴露用个人监测仪测量,潜在皮肤暴露用皮肤垫和洗手测量。通过采集叶片冲孔样本测量可去除的叶面残留物。对于呼吸道暴露和潜在皮肤暴露,在几项任务之间观察到了差异。根据与特定研究目的相关的暴露测量指标(如手部、前额、可吸入粉尘)对工人进行分类。总体而言,所有暴露测量的工人内部变异性大于工人之间的变异性。同一身体部位的皮肤暴露变异性相对于不同身体部位之间的变异性较小。水果种植者和儿子之间的总暴露差异,包括家中的暴露,较小。妻子的暴露量比水果种植者和儿子低两到三倍。由于不同任务的单位时间暴露量处于同一数量级,因此个人在这些任务上花费的时间对于估算总潜在暴露至关重要。由于工人内部变异性较大,因此需要进行重复测量以准确估算个体暴露量。