Freedman S, Fletcher C M
Br Med J. 1976 Jun 12;1(6023):1427-30. doi: 10.1136/bmj.1.6023.1427.
The effects of smoking cigarettes with 30% of the tobacco replaced by NSM tobacco substitute, which lowered their tar and nicotine delivery, were studied by comparing them with the effects of conventional cigarettes in a controlled crossover trial lasting 20 months. Chest symptoms, cigarette consumption, and forced expiratory volume in one second (FEV1) were measured each month. Two-hundred men began the trial and 159 completed it. The test cigarettes were acceptable to all but one of the men. In a subsample of 35 men estimates of nicotine intake were obtained from monthly analyses of cigarette stubs. On changing from NSM to control cigarettes six of the 17 men, who were accustomed to low nicotine, kept their nicotine intake down by some change in smoking habit. Before the crossover and this change in smoking habit the men smoking NSM cigarettes had a small but significant reduction of cough. Cigarettes containing 30% NSM and delivering only 1 mg of nicotine are likely to be acceptable to smokers and may reduce coughing. Further trials are needed to confirm these findings and establish what long-term effects such cigarettes may have on smokers' health.
在一项为期20个月的对照交叉试验中，通过将30%烟草被NSM烟草替代品取代从而降低焦油和尼古丁含量的香烟与传统香烟的效果进行比较，研究了这些香烟的效果。每月测量胸部症状、香烟消耗量和一秒用力呼气量（FEV1）。200名男性开始试验，159人完成试验。除一名男性外，所有男性都接受了测试香烟。在35名男性的子样本中，通过每月对烟蒂的分析获得尼古丁摄入量的估计值。在从NSM香烟改为对照香烟时，17名习惯低尼古丁的男性中有6人通过改变吸烟习惯保持了尼古丁摄入量。在交叉试验和这种吸烟习惯改变之前，吸NSM香烟的男性咳嗽有小幅但显著的减少。含有30%NSM且仅释放1毫克尼古丁的香烟可能会被吸烟者接受，并可能减少咳嗽。需要进一步试验来证实这些发现，并确定此类香烟对吸烟者健康可能产生的长期影响。
