Meek J H, Tyszczuk L, Elwell C E, Wyatt J S
Department of Paediatrics, University College London Medical School.
Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F33-7. doi: 10.1136/fn.78.1.f33.
To measure changes in cerebral haemodynamics over the first three days of life in very preterm infants with normal brains.
Eleven mechanically ventilated infants (median gestational age 26 weeks) without evidence of major abnormalities on cranial ultrasound examination were studied. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using near infrared spectroscopy at least twice over the first three days of life.
Cerebral blood flow increased significantly with time (p = 0.02; stepwise linear regression) and this was independent of mean arterial blood pressure, PaCO2, and haematocrit.
This change is likely to represent a normal adaptive response of the cerebral circulation to postnatal life.
测量脑结构正常的极早产儿出生后前三天的脑血流动力学变化。
对11例机械通气的婴儿（中位胎龄26周）进行研究，这些婴儿经头颅超声检查未发现重大异常。在出生后的前三天内，至少两次使用近红外光谱法测量脑血流量（CBF）和脑血容量（CBV）。
脑血流量随时间显著增加（p = 0.02；逐步线性回归），且这与平均动脉血压、动脉血二氧化碳分压和血细胞比容无关。
这种变化可能代表脑循环对出生后生活的一种正常适应性反应。
