Willers J M, Bloksma N, van der Meer C, Snippe H, van Dijk H, de Reuver M J, Hofhuis F M
Antonie Van Leeuwenhoek. 1979;45(1):41-8. doi: 10.1007/BF00400777.
Regulation of the immune response by macrophages was studied with cellular resistance to Listeria monocytogenes as parameter. The use of agents which suppress macrophage activity during the induction-phase of immunity enabled the induction of protective immunity with killed listeria. Fractionation of the cell content of listeria yielded an RNA'se sensitive fraction which in a dose of 300 ng and in combination with the cationic surfactant dimethyl dioctadecyl ammonium bromide induced protective immunity against listeria.
以对单核细胞增生李斯特菌的细胞抵抗力为参数，研究了巨噬细胞对免疫反应的调节作用。在免疫诱导期使用抑制巨噬细胞活性的药物，能够用灭活的李斯特菌诱导出保护性免疫。对李斯特菌细胞内容物进行分级分离，得到一个对RNA酶敏感的组分，该组分以300纳克的剂量并与阳离子表面活性剂二甲基二十八烷基溴化铵联合使用时，可诱导出针对李斯特菌的保护性免疫。
