Kurahashi K, Fujiwara M
Can J Physiol Pharmacol. 1976 Jun;54(3):287-93. doi: 10.1139/y76-042.
Dehydrocorydaline, an active principle of Corydalis bulbosa alkaloids, in concentrations of 10(-5) M to 5 x 10(-5)M inhibited relaxation and the concomitant release of (3H)-noradrenaline caused by 10(-4)M nicotine and electrical perivascular nerve stimulation in the taenia caecum of guinea pig. The same inhibitory effects were observed on contraction and release of (3H) noradrenaline in the sympathetic nerve-pulmonary artery preparation of rabbit. On the other hand, neither relaxation nor contraction caused by exogenously applied noradrenaline was affected. These results suggest that the inhibitory action of dehydrocorydaline on the relaxation or contraction, produced by nicotine and electrical nerve stimulation, is due to blockade of noradrenaline release from the adrenergic nerve terminals in both the taenia caecum and pulmonary artery. Participation of the adrenergic neuron blocking action of dehydrocorydaline in preventing experimental ulceration is discussed.
去氢紫堇碱是紫堇球茎生物碱的一种活性成分，浓度为10⁻⁵M至5×10⁻⁵M时，可抑制豚鼠盲肠绦虫中由10⁻⁴M尼古丁和血管周围神经电刺激引起的舒张以及伴随的（³H）-去甲肾上腺素释放。在兔交感神经-肺动脉制备物中，对（³H）去甲肾上腺素的收缩和释放也观察到了相同的抑制作用。另一方面，外源性应用去甲肾上腺素所引起的舒张或收缩均未受影响。这些结果表明，去氢紫堇碱对尼古丁和神经电刺激所产生的舒张或收缩的抑制作用，是由于其阻断了盲肠绦虫和肺动脉中肾上腺素能神经末梢的去甲肾上腺素释放。文中讨论了去氢紫堇碱的肾上腺素能神经元阻断作用在预防实验性溃疡形成中的参与情况。
