Lis A W, Mclaughlin I, MPCLAUGHLIN R K, Lis E W, Stubbs E G
Clin Chem. 1976 Sep;22(9):1528-32.
Urines from 19 autistic children (3 female, 16 male) were analyzed by high-resolution, high-pressure anion-exchange chromatography. The results showed abnormalities in the excretion of hippuric acid, 4-hydroxyhippuric acid, and N1-methyl-2-pyridone-5-carboxamide, the end product of the nicotinic acid pathway. Considerations as the metabolic origin on the 4-hydroxyhippuric acid are discussed and related to the possibility of bacterial action and malabsorption.
对19名自闭症儿童（3名女性，16名男性）的尿液进行了高分辨率、高压阴离子交换色谱分析。结果显示马尿酸、4-羟基马尿酸和烟酸途径的终产物N1-甲基-2-吡啶酮-5-甲酰胺的排泄存在异常。讨论了4-羟基马尿酸的代谢来源，并将其与细菌作用和吸收不良的可能性相关联。
