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J Clin Microbiol. 1998 Apr;36(4):1137-8. doi: 10.1128/JCM.36.4.1137-1138.1998.
2
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A globally applicable PCR-based detection and discrimination of BK and JC polyomaviruses.一种基于聚合酶链反应的、可全球应用的BK和JC多瘤病毒检测与鉴别方法。
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Analysis of cerebrospinal fluid and cerebrospinal fluid cells from patients with multiple sclerosis for detection of JC virus DNA.对多发性硬化症患者的脑脊液和脑脊液细胞进行分析以检测JC病毒DNA。
Mult Scler. 2009 Jan;15(1):28-35. doi: 10.1177/1352458508096870. Epub 2008 Sep 19.
8
JC viremia and multiple sclerosis.
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Nested PCR for detection of BK virus and JC virus DNA.用于检测BK病毒和JC病毒DNA的巢式聚合酶链反应
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2
Analysis of PCR as a tool for detection of JC virus DNA in cerebrospinal fluid for diagnosis of progressive multifocal leukoencephalopathy.聚合酶链反应（PCR）作为检测脑脊液中JC病毒DNA以诊断进行性多灶性白质脑病的工具的分析。
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Detection of enteroviral RNA by polymerase chain reaction in cerebrospinal fluid from patients with aseptic meningitis.通过聚合酶链反应检测无菌性脑膜炎患者脑脊液中的肠道病毒RNA。
Scand J Infect Dis. 1993;25(5):547-57. doi: 10.3109/00365549309008542.
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Progressive multifocal leukoencephalopathy diagnosed by amplification of JC virus-specific DNA from cerebrospinal fluid.通过从脑脊液中扩增JC病毒特异性DNA诊断的进行性多灶性白质脑病。
AIDS. 1994 Jan;8(1):49-57. doi: 10.1097/00002030-199401000-00008.
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Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.检测进行性多灶性白质脑病患者脑脊液中 JC 病毒 DNA 的诊断价值。
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JC virus DNA in cerebrospinal fluid of human immunodeficiency virus-infected patients: predictive value for progressive multifocal leukoencephalopathy.人类免疫缺陷病毒感染患者脑脊液中的JC病毒DNA：对进行性多灶性白质脑病的预测价值
Ann Neurol. 1995 Mar;37(3):395-9. doi: 10.1002/ana.410370316.
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New method for the extraction of viral RNA and DNA from cerebrospinal fluid for use in the polymerase chain reaction assay.从脑脊液中提取病毒RNA和DNA用于聚合酶链反应检测的新方法。
J Virol Methods. 1995 May;53(1):25-36. doi: 10.1016/0166-0934(94)00173-e.
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New diagnostic criteria for multiple sclerosis: guidelines for research protocols.多发性硬化症的新诊断标准：研究方案指南。
Ann Neurol. 1983 Mar;13(3):227-31. doi: 10.1002/ana.410130302.
9
Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).评估多发性硬化症的神经功能损伤：扩展残疾状态量表（EDSS）
Neurology. 1983 Nov;33(11):1444-52. doi: 10.1212/wnl.33.11.1444.
10
Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labeling, and avidin-biotin amplification.通过琼脂糖等电聚焦、双抗体过氧化物酶标记和抗生物素蛋白-生物素放大技术提高脑脊液中寡克隆IgG的检测。
Clin Chem. 1984 Jul;30(7):1246-9.

在进行性多灶性白质脑病患者的脑脊液（CSF）样本中检测到JC病毒，但在单纯疱疹病毒性脑炎、肠道病毒性脑膜炎或多发性硬化症患者的CSF样本中未检测到。

Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis.

作者信息

Bogdanovic G, Priftakis P, Hammarin A L, Söderström M, Samuelson A, Lewensohn-Fuchs I, Dalianis T

机构信息

Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

J Clin Microbiol. 1998 Apr;36(4):1137-8. doi: 10.1128/JCM.36.4.1137-1138.1998.

DOI:10.1128/JCM.36.4.1137-1138.1998
PMID:9542955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104707/
Abstract

JC virus (JCV) DNA was detected in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy (PML) but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. This suggests that inflammatory processes in the brain do not necessarily reactivate JCV, which further supports the proposal that the presence of JCV DNA in the CSF is diagnostic for PML.

摘要

在进行性多灶性白质脑病（PML）患者的脑脊液（CSF）样本中检测到JC病毒（JCV）DNA，但在单纯疱疹病毒性脑炎、肠道病毒性脑膜炎或多发性硬化症患者的CSF样本中未检测到。这表明脑部的炎症过程不一定会激活JCV，这进一步支持了CSF中JCV DNA的存在可作为PML诊断依据的提议。