在进行性多灶性白质脑病患者的脑脊液（CSF）样本中检测到JC病毒，但在单纯疱疹病毒性脑炎、肠道病毒性脑膜炎或多发性硬化症患者的CSF样本中未检测到。
Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis.
作者信息
Bogdanovic G, Priftakis P, Hammarin A L, Söderström M, Samuelson A, Lewensohn-Fuchs I, Dalianis T
机构信息
Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.
出版信息
J Clin Microbiol. 1998 Apr;36(4):1137-8. doi: 10.1128/JCM.36.4.1137-1138.1998.
Abstract
JC virus (JCV) DNA was detected in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy (PML) but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. This suggests that inflammatory processes in the brain do not necessarily reactivate JCV, which further supports the proposal that the presence of JCV DNA in the CSF is diagnostic for PML.
摘要
在进行性多灶性白质脑病（PML）患者的脑脊液（CSF）样本中检测到JC病毒（JCV）DNA，但在单纯疱疹病毒性脑炎、肠道病毒性脑膜炎或多发性硬化症患者的CSF样本中未检测到。这表明脑部的炎症过程不一定会激活JCV，这进一步支持了CSF中JCV DNA的存在可作为PML诊断依据的提议。
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