3-羟基-3-甲基戊二酸与大鼠实验性动脉粥样硬化
3-hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats.
作者信息
Yousufzai S Y, Siddiqi M
出版信息
Experientia. 1976 Aug 15;32(8):1033-4. doi: 10.1007/BF01933955.
PMID:955013
Abstract
In rats 3-hydroxy-3-methylglutaric acid effectively counteracts the lipemic and atherosclerotic response of massive doses of vitamin D2. It regressed the formation of atheromatous arterial lesions. Furthermore the significant decrease in serum beta-lipoprotein levels on HMG treatment could be due to decrease in VLDL triglyceride and cholesterol levels.
摘要
在大鼠中，3-羟基-3-甲基戊二酸能有效对抗大剂量维生素D2引起的脂血症和动脉粥样硬化反应。它使动脉粥样硬化病变的形成消退。此外，HMG治疗后血清β-脂蛋白水平显著降低可能是由于极低密度脂蛋白甘油三酯和胆固醇水平的降低。
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