金黄色葡萄球菌中的质粒-蛋白质松弛复合物
Plasmid-protein relaxation complexes in Staphylococcus aureus.
作者信息
Novick R
出版信息
J Bacteriol. 1976 Sep;127(3):1177-87. doi: 10.1128/jb.127.3.1177-1187.1976.
Abstract
Protein-deoxyribonucleic acid relaxation complexes have been demonstrated for six Staphylococcus aureus plasmids out of sixteen examined. Four of these encode stretomycin resistence, have molecular weights of about 2.7 x 10(6), and are isolated as supercoiled molecules that are virtally 100% relaxable by treatment with sodium dodecyl sulfate. It is probable that these four isolates represent a single widely disseminated plasmid species. The other two plasmids showing relaxation complexes have molecular weights of about 3 x 10(6) and encode chloramphenicol resistance. The complexes in these cases are unstable, and it has not been possible to induce more than 50% relaxation by any of the standard treatments. Ten other plasmids do not show detectable complexes. These include three penicillinase plasmids, four tetracycline-resistance plasmids, one plasmid carrying kanamycin-neomycin resistance, and finally, two chloramphenicol-resistance plasmids.
摘要
在检测的16种金黄色葡萄球菌质粒中，已证实有6种存在蛋白质 - 脱氧核糖核酸松弛复合物。其中4种编码链霉素抗性，分子量约为2.7×10⁶，以超螺旋分子形式分离，用十二烷基硫酸钠处理后几乎100%可松弛。这4种分离物很可能代表单一的广泛传播的质粒种类。另外两种显示松弛复合物的质粒分子量约为3×10⁶，编码氯霉素抗性。在这些情况下，复合物不稳定，任何标准处理都无法诱导超过50%的松弛。其他10种质粒未显示可检测到的复合物。这些包括3种青霉素酶质粒、4种四环素抗性质粒、1种携带卡那霉素 - 新霉素抗性的质粒，最后还有2种氯霉素抗性质粒。
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