Yanushpolsky E H, Best C L, Jackson K V, Clarke R N, Barbieri R L, Hornstein M D
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Assist Reprod Genet. 1998 Apr;15(4):193-7. doi: 10.1023/a:1023048318719.
The effect of endometriomas on oocyte quality, embryo quality, and pregnancy rates in in vitro fertilization (IVF) cycles was evaluated.
Forty-five women had "chocolate" cysts aspirated at the time of oocyte retrieval, and cyst fluid CA 125 levels were measured to ascertain presence of "true" endometriomas. Fifty-seven women without any complex cysts at the time of oocyte retrieval served as controls. IVF cycle outcome parameters were compared between the two groups.
Women with endometriomas experienced a significantly higher rate of early pregnancy loss compared to controls (47 vs 14%). There was also a trend toward fewer oocytes retrieved and fewer embryos reaching at least the four-cell stage 48 hr after retrieval in patients with true endometriomas vs controls.
The presence of endometriomas at the time of oocyte retrieval is associated with increased rates of early pregnancy losses. The number of oocytes retrieved and the embryo quality may also be affected adversely in the presence of endometriomas.
评估子宫内膜异位囊肿对体外受精（IVF）周期中卵母细胞质量、胚胎质量和妊娠率的影响。
45名女性在取卵时抽吸了“巧克力”囊肿，并测量了囊液CA 125水平以确定“真正的”子宫内膜异位囊肿的存在。57名在取卵时没有任何复杂囊肿的女性作为对照。比较两组的IVF周期结局参数。
与对照组相比，患有子宫内膜异位囊肿的女性早期妊娠丢失率显著更高（47%对14%）。与对照组相比，真正患有子宫内膜异位囊肿的患者在取卵后48小时获得的卵母细胞数量减少以及发育到至少四细胞阶段的胚胎数量减少也存在一定趋势。
取卵时存在子宫内膜异位囊肿与早期妊娠丢失率增加有关。在存在子宫内膜异位囊肿的情况下，获得卵母细胞的数量和胚胎质量也可能受到不利影响。
