Draczynska-Lusiak B, Doung A, Sun A Y
Department of Pharmacology, University of Missouri, Columbia 65212, USA.
Mol Chem Neuropathol. 1998 Feb;33(2):139-48. doi: 10.1007/BF02870187.
Oxidative stress in the central nervous system (CNS) may cause oxidation of lipoprotein particles. The oxidized lipoproteins may damage cellular and subcellular membranes, leading to tissue injury and cell death. Human low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) are oxidized by transition metal ions, such as Cu2+. Using PC 12 cells, we tested the cytotoxicity of oxidized LDL and VLDL. Cell death was increased in a dose-dependent manner. Antioxidants added to the incubation medium, such as vitamins E or C, or resveratrol showed some protection. Results indicated that oxidized lipoproteins may serve as an oxidative stressor, which may initiate the neuronal cell death leading to the manifestation of Alzheimer disease (AD).
中枢神经系统（CNS）中的氧化应激可能导致脂蛋白颗粒氧化。氧化的脂蛋白可能会损害细胞膜和亚细胞膜，导致组织损伤和细胞死亡。人低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）会被过渡金属离子（如Cu2+）氧化。我们使用PC12细胞测试了氧化LDL和VLDL的细胞毒性。细胞死亡呈剂量依赖性增加。添加到培养液中的抗氧化剂，如维生素E或C，或白藜芦醇显示出一定的保护作用。结果表明，氧化脂蛋白可能作为一种氧化应激源，引发神经元细胞死亡，导致阿尔茨海默病（AD）的表现。
