Gherardi R K, Chrétien F, Delfau-Larue M H, Authier F J, Moulignier A, Roulland-Dussoix D, Bélec L
Groupe d'Etude et de Recherche sour le Muscle et le Nerf, Créteil, France.
Neurology. 1998 Apr;50(4):1041-4. doi: 10.1212/wnl.50.4.1041.
To determine whether CD8 lymphoid infiltrates in nerves of patients with HIV-associated diffuse infiltrative lymphocytosis syndrome (DILS) corresponds to a lymphomatous neoplastic process or to a proliferation of T cells reactional to HIV.
DILS is characterized by persistent CD8 hyperlymphocytosis and multivisceral CD8 T-cell infiltration, which may affect peripheral nerves.
Presence of monoclonal T cells and HIV-1 proviral load were evaluated by polymerase chain reaction (PCR) techniques in frozen peripheral nerve samples from six patients with DILS neuropathy and 22 patients with other HIV-associated peripheral neuropathies, including mononeuritis multiplex (MM:6), inflammatory demyelinating polyneuropathies (IDP:6), distal sensory polyneuropathy (DSP:5), and toxic distal sensory polyneuropathy (TDSP:5).
Five of six patients with DILS showed no detectable monoclonal T-cell clones in their nerves. Nerve proviral load in DILS (6.8 +/- 0.2 log/10(5) cells) was much higher than in MM (p < 0.008), IDP (p < 0.001), DSP (p < 0.001), and TDSP (p < 0.005).
DILS neuropathy represents a separate entity among HIV-associated neuropathies. It is associated with massive HIV proviral load in nerve and must not be confused with a peripheral nerve T-cell lymphoma.
确定人类免疫缺陷病毒（HIV）相关弥漫性浸润性淋巴细胞增多综合征（DILS）患者神经中的CD8淋巴细胞浸润是对应淋巴瘤性肿瘤过程还是对HIV反应性T细胞的增殖。
DILS的特征是持续性CD8淋巴细胞增多和多脏器CD8 T细胞浸润，这可能会影响周围神经。
采用聚合酶链反应（PCR）技术，对6例DILS神经病变患者和22例其他HIV相关周围神经病变患者（包括多发性单神经炎（MM：6例）、炎性脱髓鞘性多发性神经病（IDP：6例）、远端感觉性多发性神经病（DSP：5例）和中毒性远端感觉性多发性神经病（TDSP：5例））的冷冻周围神经样本进行单克隆T细胞和HIV-1前病毒载量评估。
6例DILS患者中有5例神经中未检测到单克隆T细胞克隆。DILS患者神经中的前病毒载量（6.8±0.2 log/10(5)细胞）远高于MM患者（p<0.008）、IDP患者（p<0.001）、DSP患者（p<0.001）和TDSP患者（p<0.005）。
DILS神经病变是HIV相关神经病变中的一个独立实体。它与神经中大量的HIV前病毒载量有关，不应与周围神经T细胞淋巴瘤相混淆。
