Mendilaharsu M, De Stefani E, Deneo-Pellegrini H, Carzoglio J C, Ronco A
Registro Nacional de Cancer, Instituto Nacional de Oncologia, Montevideo, Uruguay.
Lung Cancer. 1998 Feb;19(2):101-7. doi: 10.1016/s0169-5002(97)00075-5.
This study investigated the effect of drinking tea or coffee on the lung cancer risk of male cigarette smokers in a case-control in Uruguay. Four hundred and twenty-seven lung cancer cases were frequency matched on age and residence with 428 hospitalized controls suffering from conditions unrelated to tobacco smoking and diet. Whereas coffee drinking had no effect on the lung cancer risk of the cigarette-smoking men in this study, black tea consumption decreased this risk. Heavy drinkers of tea (two or more cups of tea per day) were associated with a reduced risk of 0.34 (95% CI 0.14-0.84). This protective effect was more evident among Kreyberg I tumors (squamous cell and small cell) and among light smokers. Possible sources of bias and mechanisms of action are discussed.
这项研究在乌拉圭的一项病例对照研究中，调查了喝茶或咖啡对男性吸烟人群患肺癌风险的影响。427例肺癌病例在年龄和居住地方面与428名因与吸烟和饮食无关的疾病而住院的对照者进行了频数匹配。在本研究中，喝咖啡对吸烟男性的肺癌风险没有影响，而饮用红茶则降低了这种风险。重度饮茶者（每天饮用两杯或更多杯茶）患癌风险降低了0.34（95%可信区间为0.14 - 0.84）。这种保护作用在克雷伯格I型肿瘤（鳞状细胞癌和小细胞癌）患者以及轻度吸烟者中更为明显。文中讨论了可能的偏倚来源和作用机制。
