已知致癌DNA病毒未参与EB病毒阴性霍奇金淋巴瘤的发生。
Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease.
作者信息
Armstrong A A, Shield L, Gallagher A, Jarrett R F
机构信息
LRF Virus Centre, University of Glasgow, UK.
出版信息
Br J Cancer. 1998 Apr;77(7):1045-7. doi: 10.1038/bjc.1998.174.
Abstract
Epstein-Barr virus (EBV) is associated with around one-third of cases, but young adult cases are rarely EBV associated. In this study, known oncogenic DNA viruses, including human adenoviruses, papovaviruses and the human herpesviruses-6 (HHV-6) and -8 (HHV-8) were not detected in Hodgkin's disease lesions. These results suggest that an as yet unidentified infectious agent is involved in the pathogenesis of non-EBV-associated Hodgkin's disease.
摘要
爱泼斯坦-巴尔病毒（EBV）与约三分之一的病例相关，但年轻成人病例很少与EBV相关。在本研究中，在霍奇金病病变中未检测到已知的致癌DNA病毒，包括人类腺病毒、乳头多瘤空泡病毒以及人类疱疹病毒6型（HHV-6）和8型（HHV-8）。这些结果表明，一种尚未确定的感染因子参与了非EBV相关霍奇金病的发病机制。
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