阿司匹林类药物通过金属阳离子螯合作用导致胃肠道损伤。
Aspirin-like drugs cause gastrointestinal injuries by metallic cation chelation.
作者信息
Wang X
机构信息
Department of Pathology, Cornell University Medical College, New York, NY 10021, USA.
出版信息
Med Hypotheses. 1998 Mar;50(3):227-38. doi: 10.1016/s0306-9877(98)90023-8.
PMID:9578328
Abstract
Aspirin-like (nonsteroidal anti-inflammatory) drugs may cause injuries including ulcers to the gastrointestinal tract by chelation of the divalent and/or multivalent metallic cations in the gastrointestinal mucus and mucosa, as suggested by the chemical properties of these drugs and supported by experimental and clinical data.
摘要
阿司匹林样（非甾体抗炎）药物可能会通过螯合胃肠道黏液和黏膜中的二价和/或多价金属阳离子，导致包括溃疡在内的胃肠道损伤，这些药物的化学性质表明了这一点，实验和临床数据也提供了支持。
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