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Antimicrob Agents Chemother. 1998 May;42(5):1274-7. doi: 10.1128/AAC.42.5.1274.
2
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Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies.采用最低杀菌浓度（MBC）试验、体外时间杀菌和体内时间杀菌研究，比较克林沙星、CI-990和环丙沙星对细菌的根除效果。
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Comparative activity of clinafloxacin and nine other compounds tested against 2000 contemporary clinical isolates from patients in United States hospitals.克林沙星与其他九种化合物针对美国医院2000株当代临床分离株的比较活性。
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Comparative activities of clinafloxacin against gram-positive and -negative bacteria.克林沙星对革兰氏阳性菌和阴性菌的比较活性。
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In vitro activity of sparfloxacin compared with ciprofloxacin and ofloxacin against respiratory tract pathogens.司帕沙星与环丙沙星及氧氟沙星相比对呼吸道病原体的体外活性。
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本文引用的文献

1
Pharmacokinetics and inflammatory fluid penetration of clinafloxacin.克林沙星的药代动力学和炎性液体渗透情况
Antimicrob Agents Chemother. 1998 Feb;42(2):428-30. doi: 10.1128/AAC.42.2.428.
2
The tolerance and pharmacokinetics of clinafloxacin (CI-960) in healthy subjects.健康受试者中克林沙星（CI-960）的耐受性和药代动力学
J Antimicrob Chemother. 1996 Dec;38(6):1023-9. doi: 10.1093/jac/38.6.1023.
3
In vitro susceptibility of anaerobes to quinolones in the United States.美国厌氧菌对喹诺酮类药物的体外敏感性
Clin Infect Dis. 1996 Dec;23 Suppl 1:S2-8. doi: 10.1093/clinids/23.supplement_1.s2.
4
The comparative in vitro activity of clinafloxacin and other antimicrobials against vancomycin-susceptible and vancomycin-resistant enterococci.克林沙星与其他抗菌药物对万古霉素敏感和耐药肠球菌的体外比较活性。
Chemotherapy. 1996 Jul-Aug;42(4):235-9. doi: 10.1159/000239449.
5
In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci.克林沙星、CI-990（PD 131112）和PD 138312对肠球菌的体外和体内活性
Antimicrob Agents Chemother. 1995 Sep;39(9):2123-7. doi: 10.1128/AAC.39.9.2123.
6
Susceptibilities of 123 Xanthomonas maltophilia strains to clinafloxacin, PD 131628, PD 138312, PD 140248, ciprofloxacin, and ofloxacin.123株嗜麦芽窄食单胞菌对克林沙星、PD 131628、PD 138312、PD 140248、环丙沙星和氧氟沙星的敏感性。
Antimicrob Agents Chemother. 1994 Feb;38(2):369-70. doi: 10.1128/AAC.38.2.369.
7
In-vitro activity of clinafloxacin (CI-960) and PD 131628-2 against anaerobic bacteria.克林沙星（CI-960）和PD 131628-2对厌氧菌的体外活性
J Antimicrob Chemother. 1994 Oct;34(4):579-84. doi: 10.1093/jac/34.4.579.
8
Susceptibility of ciprofloxacin-resistant staphylococci and enterococci to clinafloxacin.耐环丙沙星葡萄球菌和肠球菌对克林沙星的敏感性
Diagn Microbiol Infect Dis. 1995 Jan;21(1):27-31. doi: 10.1016/0732-8893(94)00143-k.
9
Modifications for disk diffusion susceptibility testing criteria of clinafloxacin (CI-960, AM-1091, PD127371) and fleroxacin (Ro 23-6240, AM-833) following studies with a challenge panel of ciprofloxacin-resistant clinical isolates.在使用一组耐环丙沙星临床分离株进行挑战研究后，对克林沙星（CI-960、AM-1091、PD127371）和氟罗沙星（Ro 23-6240、AM-833）的纸片扩散药敏试验标准的修改。
Diagn Microbiol Infect Dis. 1995 Apr;21(4):209-13. doi: 10.1016/0732-8893(94)00061-z.
10
Activities of three investigational fluoroquinolones (BAY y 3118, DU-6859a, and clinafloxacin) against Neisseria gonorrhoeae isolates with diminished susceptibilities to ciprofloxacin and ofloxacin.三种研究性氟喹诺酮类药物（BAY y 3118、DU-6859a和克林沙星）对环丙沙星和氧氟沙星敏感性降低的淋病奈瑟菌分离株的活性。
Antimicrob Agents Chemother. 1995 Jul;39(7):1606-8. doi: 10.1128/AAC.39.7.1606.

克林沙星对来自北美10个中心的当代临床分离菌株的体外活性。

In vitro activities of clinafloxacin against contemporary clinical bacterial isolates from 10 North American centers.

作者信息

Fuchs P C, Barry A L, Brown S D

机构信息

The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.

出版信息

Antimicrob Agents Chemother. 1998 May;42(5):1274-7. doi: 10.1128/AAC.42.5.1274.

DOI:10.1128/AAC.42.5.1274
PMID:9593166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105802/
Abstract

Clinafloxacin was more active than ciprofloxacin against 4,213 aerobic and facultative anaerobic bacterial isolates from 10 medical centers, as tested by broth microdilution and disk diffusion methods. The percentage of 201 anaerobes susceptible to clinafloxacin by broth microdilution was comparable to cefoxitin. Our data support the proposed disk diffusion interpretive criteria for aerobic bacteria with 5-microg clinafloxacin disks.

摘要

通过肉汤微量稀释法和纸片扩散法检测发现，对于来自10个医学中心的4213株需氧菌和兼性厌氧菌分离株，克林沙星比环丙沙星更具活性。通过肉汤微量稀释法检测，201株厌氧菌对克林沙星的敏感率与头孢西丁相当。我们的数据支持了针对5微克克林沙星纸片对需氧菌的纸片扩散法解释标准。