来自药用植物黄花羽叶楸的抗病毒苯丙素苷类化合物。

Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea.

作者信息

Kernan M R, Amarquaye A, Chen J L, Chan J, Sesin D F, Parkinson N, Ye Z, Barrett M, Bales C, Stoddart C A, Sloan B, Blanc P, Limbach C, Mrisho S, Rozhon E J

机构信息

Shaman Pharmaceuticals, 213 East Grand Avenue, South San Francisco, California, 94080-4812, USA.

出版信息

J Nat Prod. 1998 May;61(5):564-70. doi: 10.1021/np9703914.

DOI:10.1021/np9703914

PMID:9599250

Abstract

Three new phenylpropanoid glycosides, named luteoside A (3), luteoside B (4), and luteoside C (5), were isolated together with the known compounds verbascoside (1) and isoverbascoside (2) from the roots of the medicinal plant Markhamia lutea. The structures of the new compounds were determined to be 1-O-(3, 4-dihydroxyphenyl)ethyl beta-D-apiofuranosyl(1-->2)-alpha-l-rhamnopyranosyl(1-->3)-4-O- caffeo yl-6-acetyl-beta-d-glucopyranoside, 1-O-(3,4-dihydroxyphenyl)ethyl beta-d-apiofuranosyl(1-->2)-alpha-l-rhamnopyranosyl(1-->3)-6-O- caffeo yl-beta-d-glucopyranoside, and 1-O-(3,4-dihydroxyphenyl)ethyl beta-D-apiofuranosyl(1-->2)-alpha-l-rhamnopyranosyl(1-->3)-6-O- ferulo yl-beta-d-glucopyranoside, respectively, on the basis of chemical and spectroscopic data. All five phenylpropanoid glycosides exhibited potent in vitro activity against respiratory syncytial virus.

摘要

从药用植物黄花羽叶楸的根中分离出三种新的苯丙素苷，分别命名为木犀草苷A（3）、木犀草苷B（4）和木犀草苷C（5），同时还分离出了已知化合物毛蕊花糖苷（1）和异毛蕊花糖苷（2）。根据化学和光谱数据，确定这三种新化合物的结构分别为1-O-(3,4-二羟基苯基)乙基-β-D-芹菜呋喃糖基(1→2)-α-L-鼠李吡喃糖基(1→3)-4-O-咖啡酰基-6-乙酰基-β-D-葡萄糖吡喃糖苷、1-O-(3,4-二羟基苯基)乙基-β-D-芹菜呋喃糖基(1→2)-α-L-鼠李吡喃糖基(1→3)-6-O-咖啡酰基-β-D-葡萄糖吡喃糖苷和1-O-(3,4-二羟基苯基)乙基-β-D-芹菜呋喃糖基(1→2)-α-L-鼠李吡喃糖基(1→3)-6-O-阿魏酰基-β-D-葡萄糖吡喃糖苷。所有这五种苯丙素苷均表现出对呼吸道合胞病毒的强大体外活性。