Ni Y H, Lin H H, Chen P J, Hsu H Y, Chen D S, Chang M H
Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, R.O.C.
J Hepatol. 1994 May;20(5):641-5. doi: 10.1016/s0168-8278(05)80353-8.
To investigate mother-to-infant transmission of hepatitis C virus, serial follow-up of anti-HCV and hepatitis C virus RNA was undertaken in 11 infants born to hepatitis C virus-infected mothers who had been screened from 11,688 pregnant women. None of the hepatitis C virus-infected mothers was infected by human immunodeficiency virus. Anti-HCV was checked by the second-generation enzyme immunoassay kit, and hepatitis C virus RNA was examined by reverse transcriptase-nested polymerase chain reaction. Hepatitis C virus RNA was found in more than two serum samples in two of these 11 infants; those two infants were regarded as hepatitis C virus-infected. One of the two had hepatitis C virus RNA at the age of 1, 3, and 6 months, but not later. The course of hepatitis C virus RNA and anti-HCV in this baby may reflect fluctuating viral replication in chronic infectious disease or viral clearance in acute infection. The other infant had hepatitis C virus RNA detectable at the age of 3 months and at 15, 18 and 24 months. In the other nine non-hepatitis C virus-infected infants, maternally acquired anti-HCV gradually disappeared by the age of 6 months. The liver function profile fell to the normal range in all the infants, including the two hepatitis C virus-infected infants. This may indicate the subclinical nature of hepatitis C virus infection in infancy. Seven fathers and four siblings of these 11 infants were checked for anti-HCV and liver function tests; none had evidence of hepatitis C virus infection.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究丙型肝炎病毒的母婴传播情况，对11名丙型肝炎病毒感染母亲所生的婴儿进行了抗-HCV和丙型肝炎病毒RNA的系列随访，这些母亲是从11688名孕妇中筛查出来的。所有丙型肝炎病毒感染母亲均未感染人类免疫缺陷病毒。采用第二代酶免疫分析试剂盒检测抗-HCV，并用逆转录巢式聚合酶链反应检测丙型肝炎病毒RNA。在这11名婴儿中的2名婴儿的两份以上血清样本中检测到丙型肝炎病毒RNA；这两名婴儿被视为丙型肝炎病毒感染。其中一名婴儿在1、3和6个月时检测到丙型肝炎病毒RNA，但之后未检测到。该婴儿体内丙型肝炎病毒RNA和抗-HCV的变化过程可能反映了慢性感染中病毒复制的波动或急性感染中病毒的清除。另一名婴儿在3个月、15、18和24个月时均检测到丙型肝炎病毒RNA。在其他9名未感染丙型肝炎病毒的婴儿中，母体获得的抗-HCV在6个月龄时逐渐消失。所有婴儿，包括两名丙型肝炎病毒感染婴儿的肝功能指标均降至正常范围。这可能表明婴儿期丙型肝炎病毒感染具有亚临床性质。对这11名婴儿的7名父亲和4名兄弟姐妹进行了抗-HCV和肝功能检查；均无丙型肝炎病毒感染的证据。（摘要截短至250字）
