Demers L M, Gabbe S G
Am J Obstet Gynecol. 1976 Sep 1;126(1):137-9. doi: 10.1016/0002-9378(76)90478-6.
Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.
子痫前期的特征是子宫胎盘缺血。前列腺素可改变全身血压，并调节流向胎儿-胎盘单位的血流。在本研究中，子痫前期患者胎盘组织中前列腺素E水平显著降低。强效血管收缩剂前列腺素F则明显升高。这些观察结果表明，胎盘前列腺素代谢改变是子痫前期病理生理学中的一个重要因素。
