Schäfer Elinder L, Frostegård J
Konung Gustaf V:s Forskningsinstitut, Karolinska institutet, Stockholm.
Lakartidningen. 1998 May 6;95(19):2203-6.
The importance of vascular inflammation in the atherosclerotic process is receiving increasing attention. Several infections have been linked with cardiovascular disease and atherogenesis, and the risk of cardiovascular manifestations has been found to be increased in the presence of autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus. Inflammatory cytokines have been shown to induce changes in lipid metabolism and endothelial function, which may result in arterial disease. These recent advances in our knowledge may provide a basis for the development of new strategies for the prevention and treatment of atherosclerosis and cardiovascular disease.
血管炎症在动脉粥样硬化过程中的重要性正受到越来越多的关注。几种感染已与心血管疾病和动脉粥样硬化的发生相关联，并且已发现，在存在类风湿性关节炎或系统性红斑狼疮等自身免疫性疾病的情况下，心血管表现的风险会增加。炎症细胞因子已被证明可诱导脂质代谢和内皮功能的变化，这可能导致动脉疾病。我们在这方面知识的这些最新进展可能为开发预防和治疗动脉粥样硬化及心血管疾病的新策略提供基础。
