Tavani A, Ferraroni M, Mezzetti M, Franceschi S, Lo Re A, La Vecchia C
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Nutr Cancer. 1998;30(3):213-9. doi: 10.1080/01635589809514666.
The relationship between alcohol drinking (mainly wine) and risk of colon and rectal cancer was considered in a case-control study conducted between 1991 and 1996 in six Italian centers. Cases were 1,225 patients < 75 years of age with histologically confirmed cancer of the colon and 728 patients with cancer of the rectum; controls were 4,154 patients admitted to hospital for a wide spectrum of acute, nonneoplastic diseases. Compared with never drinkers, the odds ratios (OR) for current drinkers in the higher quintile of total alcohol intake (> 51.82 g ethanol/day) were 1.01 for colon cancer and 0.90 for rectal cancer, and those for ex-drinkers were 1.20 and 1.07, respectively. The OR for wine drinkers in the highest quartile of intake were 1.07 for colon cancer and 0.97 for rectal cancer. No association was found with duration of the habit, time since starting, or age at starting. Among ex-drinkers, no association appeared with time since stopping. No significant heterogeneity was found across strata of age at diagnosis, sex, education, smoking status, physical activity, family history of colorectal cancer, beta-carotene, vitamin C, coffee, total fiber and folate intake, and number of meals per day. No significant association appeared for various intestinal subsites.
1991年至1996年期间，在意大利的六个中心开展了一项病例对照研究，探讨饮酒（主要是葡萄酒）与结肠癌和直肠癌风险之间的关系。病例组为1225名年龄小于75岁、经组织学确诊的结肠癌患者和728名直肠癌患者；对照组为4154名因各种急性非肿瘤性疾病入院的患者。与从不饮酒者相比，总酒精摄入量处于最高五分位数（>51.82克乙醇/天）的当前饮酒者患结肠癌的比值比（OR）为1.01，患直肠癌的比值比为0.90；既往饮酒者的比值比分别为1.20和1.07。葡萄酒摄入量处于最高四分位数的饮酒者患结肠癌的OR为1.07，患直肠癌的OR为0.97。未发现与饮酒习惯的持续时间、开始饮酒时间或开始饮酒年龄有关联。在既往饮酒者中，未发现与戒酒时间有关联。在诊断时的年龄、性别、教育程度、吸烟状况、身体活动、结直肠癌家族史、β-胡萝卜素、维生素C、咖啡、总纤维和叶酸摄入量以及每日进餐次数等分层中，未发现显著的异质性。在不同的肠道亚部位未发现显著关联。
