Pedersen A, Johansen C, Grønbaek M
Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen Hospital Corporation, Denmark.
Gut. 2003 Jun;52(6):861-7. doi: 10.1136/gut.52.6.861.
There may be a weak association between total alcohol intake and colorectal cancer but the effect of different types of alcohol and effect on colon subsites have not been investigated satisfactorily.
To investigate the relationship between amount and type of alcohol and the risk of colon and rectal cancer.
A population based cohort study with baseline assessment of weekly intake of beer, wine, and spirits, smoking habits, body mass index, educational level, and leisure time physical activity in Copenhagen, Denmark. The study included a random sample of 15 491 men and 13 641 women, aged 23-95 years. Incident cases of colorectal cancer were identified in the nationwide Danish Cancer Register.
During a mean follow up of 14.7 years, we observed 411 colon cancers and 202 rectal cancers. We observed a dose-response relationship between alcohol and rectal cancer. Drinkers of more than 41 drinks a week had a relative risk of rectal cancer of 2.2 (95% confidence limits 1.0-4.6) compared with non-drinkers. Drinkers of more than 14 drinks of beer and spirits a week, but not wine, had a risk of 3.5 (1.8-6.9) of rectal cancer compared with non-drinkers, while those who drank the same amount of alcohol but including more than 30% of wine had a risk of 1.8 (1.0-3.2) of rectal cancer. No relation between alcohol and colon cancer was found when investigating the effects of total alcohol, beer, wine, and spirits, and percentage of wine of total alcohol intake.
Alcohol intake is associated with a significantly increased risk of rectal cancer but the risk seems to be reduced when wine is included in the alcohol intake.
总酒精摄入量与结直肠癌之间可能存在微弱关联，但不同类型酒精的影响以及对结肠不同部位的影响尚未得到充分研究。
调查酒精的摄入量和类型与结肠癌和直肠癌风险之间的关系。
一项基于人群的队列研究，对丹麦哥本哈根的啤酒、葡萄酒和烈酒每周摄入量、吸烟习惯、体重指数、教育水平和休闲时间身体活动进行基线评估。该研究包括15491名男性和13641名女性的随机样本，年龄在23 - 95岁之间。在丹麦全国癌症登记处确定结直肠癌的发病病例。
在平均14.7年的随访期间，我们观察到411例结肠癌和202例直肠癌。我们观察到酒精与直肠癌之间存在剂量反应关系。每周饮酒超过41杯的人患直肠癌的相对风险为2.2（95%置信区间1.0 - 4.6），而不饮酒者为1。每周饮用超过14杯啤酒和烈酒但不包括葡萄酒的人患直肠癌的风险为3.5（1.8 - 6.9），而饮用相同量酒精但其中葡萄酒占比超过30%的人患直肠癌的风险为1.8（1.0 - 3.2）。在研究总酒精、啤酒、葡萄酒和烈酒的影响以及葡萄酒在总酒精摄入量中的百分比时，未发现酒精与结肠癌之间存在关联。
酒精摄入与直肠癌风险显著增加相关，但当酒精摄入中包含葡萄酒时，风险似乎会降低。
