Emerman M, Malim M H
Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North-Mailstop C2-023, Seattle, Washington 98109-1024, USA.
Science. 1998 Jun 19;280(5371):1880-4. doi: 10.1126/science.280.5371.1880.
Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.
1型人类免疫缺陷病毒（HIV-1）以复杂的方式操控宿主细胞的基本过程，以实现最佳复制效率。最近的研究提供了关于HIV-1与其宿主细胞分子相互作用的新细节。例如，HIV-1编码一种通过与细胞周期蛋白依赖性激酶相互作用来调节转录延伸的蛋白质，另一种激活病毒RNA的特异性核输出，还有几种影响病毒和宿主细胞蛋白质的细胞内运输。对这些病毒蛋白与正常细胞活动之间相互作用的详细分析，为病毒学和宿主细胞生物学的核心问题提供了新的见解。
