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从人类分离出的甲型禽流感病毒的特性——大流行性流感病毒的出现是否需要中间宿主?

Characterisation of an avian influenza A virus isolated from a human--is an intermediate host necessary for the emergence of pandemic influenza viruses?

作者信息

Banks J, Speidel E, Alexander D J

机构信息

Central Veterinary Laboratory (Weybridge), Addlestone, Surrey, U.K.

出版信息

Arch Virol. 1998;143(4):781-7. doi: 10.1007/s007050050329.

DOI:10.1007/s007050050329
PMID:9638147
Abstract

The partial sequencing of the internal and the neuraminidase genes of isolate 268/96 obtained from a woman with conjunctivitis showed all seven to have closest homology with avian influenza viruses. The entire nucleotide sequence of the haemagglutinin gene of 268/96 had close, 98.2%, homology with an H7N7 virus isolated from turkeys in Ireland in 1995. This appears to be the first reported case of isolation of an influenza A virus from a human being infected as a result of direct natural transmission of an avian influenza virus from birds.

摘要

从一名患结膜炎妇女身上分离出的268/96毒株的内部基因和神经氨酸酶基因的部分测序显示,所有七个基因与禽流感病毒的同源性最高。268/96毒株血凝素基因的完整核苷酸序列与1995年在爱尔兰从火鸡中分离出的H7N7病毒有密切的同源性,同源性为98.2%。这似乎是首次报道的因禽流感病毒从禽类直接自然传播而感染人类并从中分离出甲型流感病毒的病例。

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